Περίληψη:
Background: Polymorphisms of the vitamin D receptor (VDR) gene have been
implicated in the genetic regulation of bone mineral density (BMD).
However, the clinical impact of these variants remains unclear.
Objective: To evaluate the relation between VDR polymorphisms, BMD, and
fractures.
Design: Prospective multicenter large-scale association study.
Setting: The Genetic Markers for Osteoporosis consortium, involving 9
European research teams.
Participants: 26242 participants (18405 women).
Measurements: Cdx2 promoter, FokI, BsmI, ApaI, and TaqI polymorphisms;
BMD at the femoral neck and the lumbar spine by dual x-ray
absorptiometry; and fractures.
Results: Comparisons of BMD at the lumbar spine and femoral neck showed
nonsignificant differences less than 0.011 g/cm(2) for any genotype with
or without adjustments. A total of 6067 participants reported a history
of fracture, and 2088 had vertebral fractures. For all VDR alleles, odds
ratios for fractures were very close to 1.00 (range, 0.98 to 1.02) and
collectively the 95% CIs ranged from 0.94 (lowest) to 1.07 (highest).
For vertebral fractures, we observed a 9% (95% CI, 0% to 18%; P =
0.039) risk reduction for the Cdx2 A-allele (13% risk reduction in a
dominant model).
Limitations: The authors analyzed only selected VDR polymorphisms.
Heterogeneity was detected in some analyses and may reflect some
differences in collection of fracture data across cohorts. Not all
fractures were related to osteoporosis.
Conclusions: The FokI, BsmI, ApaI, and TaqI VDR polymorphisms are not
associated with BMD or with fractures, but the Cdx2 polymorphism may be
associated with risk for vertebral fractures.
Συγγραφείς:
Uitterlinden, Andre G.
Ralston, Stuart H.
Brandi, Maria Luisa
and Carey, Alisoun H.
Grinberg, Daniel
Langdahl, Bente L. and
Lips, Paul
Lorenc, Roman
Obermayer-Pietsch, Barbara
Reeve,
Jonathan
Reid, David M.
Amidei, Antonietta
Bassiti, Amelia
and Bustamante, Mariona
Husted, Use Bjerre
Diez-Perez, Adolfo
and Dobnig, Harald
Dunning, Alison M.
Enjuanes, Anna and
Fahrleitner-Pammer, Astrid
Fang, Yue
Karczmarewicz, Elzbieta and
Kruk, Marcin
van Leeuwen, Johannes P. T. M.
Mavilia, Carmelo and
van Meurs, Joyce B. J.
Mangion, Jon
McGuigan, Fiona E. A. and
Pols, Huibert A. P.
Renner, Wilfried
Rivadeneira, Fernando and
van Schoor, Natasja M.
Scollen, Serena
Sherlock, Rachael E. and
Ioannidis, John P. A.
APOSS Investigators
EPOS Investigators and
EPOLOS Investigators
FAMOS Investigators
LASA Investigators and
Rotterdam Study Investigators
GENOMOS Study
