Τίτλος:
Conventional and molecular investigation of meningococcal isolates in
relation to two outbreaks in the area of Athens, Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Two local outbreaks caused by serogroup B Neisseria meningitidis
occurred in the Athens area of Greece during 2003. In total, 30 N.
meningitidis isolates from patients and carriers, as well as sporadic
cases, were investigated by conventional techniques (serogroup, serotype
and serosubtype), multilocus sequence typing (MLST), analysis of
variable number tandem repeats (VNTR) and random amplified polymorphic
DNA (RAPD) analysis. Compared with the two other molecular techniques,
VNTR analysis was a simple, reliable and highly discriminatory method
for fine typing of meningococcal isolates, showing a good correlation
with the epidemiological data for the two outbreaks analysed.
Συγγραφείς:
Tzanakaki, G.
Kesanopoulos, K.
Yazdankhah, S. P.
Levidiotou,
S.
Kremastinou, J.
Caugant, D. A.
Περιοδικό:
Clinical Microbiology and Infection
Εκδότης:
Blackwell Publishing Inc.
Λέξεις-κλειδιά:
multilocus sequence typing; Neisseria meningtidis; outbreaks; random
amplified polymorphic DNA; typing; variable number tandem repeats
DOI:
10.1111/j.1469-0691.2006.01521.x
