Περίληψη:
Introduction: The objective of the current study was to analyze the
potential value of immunocytochemical analysis on ThinPrep (TP)
-processed smears, from fine needle aspiration (FNA) biopsies, of breast
tumors for the determination of ER and PIR content as compared with the
immunohistochemical analysis performed on paraffin -embedded breast
tumor specimens.
Patients and methods: Percutaneous FINA biopsy of focal breast Lesions
in 119 female adult patients during a 31 -month period was performed.
Subsequently, these patients underwent surgical resection of the tumors.
ER and PR status of the tumors was determined by immunocytochemical
analysis on TP-processed smears and by immunohistochemical studies in
paraffin -embedded sections.
Results: With the use of TP technique adequate material was observed in
all cases. Sensitivity, specificity, positive predictive value (PPV),
negative predictive value (NPV) and overall accuracy (OA) of the TP
technique for the ER were 98.95%, 100%, 100%, 95.84% and 99.15%
respectively. In addition, sensitivity, specificity, PPV, NPV and OA of
the TP technique for the PR were 100%, 87.5%, 95.60%, 100% and
96.64%, respectively.
Conclusions: ER and PR status can be evaluated in FNA material from
breast carcinomas by using the TP technique. Sample collection and
storage is simple and permits the assortment of the FNA sample for both
morphotogic diagnosis and ancillary studies. The accuracy of TP
technique in the detection of ER and PR content is comparable to those
of the histological evaluation, and could be of paramount importance for
the preoperative planning of treatment. (c) 2007 Elsevier Ltd. All
rights reserved.
Συγγραφείς:
Konofaos, P.
Kontzoglou, K.
Georgoulakis, J.
Megatopoulou,
T.
Zoumpouli, C.
Christoni, Z.
Papadopoulos, P. and
Kouraklis, G.
Karakitsos, P.
