Περίληψη:
The prognostic value of baseline serum free light chain ratio (sFLCR)
was investigated in 94 multiple myeloma (MM) patients. sFLCR was
calculated as kappa/lambda or lambda/kappa, depending on the patients’
dominating monoclonal light chain. Median baseline sFLCR was 3.57 in
kappa-MM patients, 45.09 in lambda-MM. ‘High’ sFLCR (>= the observed
median value for kappa- and lambda-MM respectively) correlated with
elevated serum creatinine and lactate dehydrogenase, extensive marrow
infiltration and light chain type MM. The 5-year disease-specific
survival was 82% and 30% in patients with sFLCR lower than and equal
or greater than the median, respectively (P = 0.0001). sFLCR was an
independent prognostic factor.
Συγγραφείς:
Kyrtsonis, Marie-Christine
Vassilakopoulos, Theodoros P.
Kafasi,
Nicoletta
Sachanas, Sotirios
Tzenou, Tatiana
Papadogiannis,
Argiroula
Galanis, Zacharoula
Kalpadakis, Christina
Dimou,
Maria
Kyriakou, Elias
Angelopoulou, Maria K.
Dimopoulou,
Maria N.
Siakantaris, Marina P.
Dimitriadou, Evangelia M. and
Kokoris, Styliani I.
Panayiotidis, Panayiotis
Pangalis,
Gerassimos A.
