Περίληψη:
Objective: Aortic stiffness and wave reflections are important markers
and prognosticators of cardiovascular risk. Caffeine increases acutely
aortic stiffness and wave reflections. Furthermore, chronic coffee
consumption is associated with increased aortic stiffness and wave
reflections in normotensive subjects. In the present study, we aimed to
assess the association between chronic coffee consumption, and aortic
stiffness and wave reflections in hypertensive patients.
Design: Epidemiological survey.
Setting: Hypertension Unit, University Hospital.
Subjects-methods: We examined 259 never-treated hypertensives (age 50712
years, 165 males) without diabetes mellitus, who were asked to describe
in detail the type and amount of coffee they consumed. Carotid-femoral
pulse wave velocity (PWV) and augmentation index (Alx) were measured
non-invasively as indices of aortic stiffness and wave reflections,
respectively.
Results: When controlled for gender, age, height, smoking status, heart
rate, mean pressure, HDL cholesterol and hsCRP, Alx was found to be
higher with increasing daily coffee consumption. Post hoc analysis
revealed that all groups of coffee consumption had higher Alx compared
to no-consumption. PWV did not differ among groups of daily coffee
consumption. Each participant had 35% higher relative risk of having
high Alx for each cup (150 ml) of coffee per day, and 40% higher
relative risk for each 10 cup-years.
Conclusions: Coffee consumption is associated with increased wave
reflections, but not aortic stiffness in never-treated hypertensive
patients. This finding may have important clinical implications for
cardiovascular health in hypertensive subjects.
Συγγραφείς:
Vlachopoulos, C. V.
Vyssoulis, G. G.
Alexopoulos, N. A. and
Zervoudaki, A. I.
Pietri, P. G.
Aznaouridis, K. A. and
Stefanadis, C. I.
