Τίτλος:
Galectins-1, -3, -7, -8 and -9 as prognostic markers for survival in epithelial ovarian cancer: A systematic review and meta-analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Galectins are a family of proteins that have recently emerged as regulators of cancer biology. Objectives: To investigate the impact of peritumoral and tumoral galectin expression on ovarian cancer prognosis. Search strategy: We searched Medline, Cochrane, and EMBASE databases from inception until March 22, 2020. Selection criteria: All studies correlating galectins and ovarian cancer prognosis were selected. Data collection and analysis: The literature search presented 11 studies, which contained 1034 patients. Meta-analysis was performed with RevMan 5.3 software. Main results: Studies were stratified into two groups depending on the location of galectin expression (peritumoral stroma or nucleus/cytoplasm of tumor cells). Tumoral galectin-7 and galectin-9 expression was significantly associated with poor overall survival (odds ratio [OR] 2.06, 95% confidence interval [CI] 1.32–3.21, P = 0.001; OR 1.71, 95% CI 1.27–2.30, P < 0.001, respectively). The total effect of high tumoral expression of galectins in overall survival and progression-free survival was significant (OR 1.51, 95% CI 1.02–2.23, P = 0.04; OR 2.76, 95% CI 1.73–4.40, P < 0.001, respectively). Conclusions: Our results suggest that galectins are implicated in ovarian cancer prognosis; however, further research is needed to ascertain their actual importance as well as their diagnostic accuracy. © 2020 International Federation of Gynecology and Obstetrics
Συγγραφείς:
Pergialiotis, V.
Papoutsi, E.
Androutsou, A.
Tzortzis, A.-S.
Frountzas, M.
Papapanagiotou, A.
Kontzoglou, K.
Περιοδικό:
International Journal of Gynecology and Obstetrics
Εκδότης:
John Wiley and Sons Ltd
Λέξεις-κλειδιά:
ecalectin; galectin 1; galectin 3; galectin 7; galectin 8; galectin; galectin 1; galectin 3; LGALS1 protein, human; LGALS7 protein, human; LGALS9 protein, human; tumor marker, adult; cancer prognosis; cancer recurrence; cancer staging; cancer survival; diagnostic accuracy; female; gene expression; histopathology; human; lymph node metastasis; major clinical study; meta analysis; ovary carcinoma; overall survival; priority journal; progression free survival; protein expression; Review; systematic review; tumor volume; blood; mortality; ovary tumor; predictive value; prognosis, Biomarkers, Tumor; Carcinoma, Ovarian Epithelial; Female; Galectin 1; Galectin 3; Galectins; Humans; Ovarian Neoplasms; Predictive Value of Tests; Prognosis
