Τίτλος:
Antigen-presenting cells in ocular surface diseases
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To review the role of antigen-presenting cells (APC) in the pathogenesis of ocular surface diseases (OSD). Methods: A thorough literature search was performed in PubMed database. An additional search was made in Google Scholar to complete the collected items. Results: APCs have the ability to initiate and direct immune responses and are found in most lymphoid and non-lymphoid tissues. APCs continuously sample their environment, present antigens to T cells and co-ordinate immune tolerance and responses. Many different types of APCs have been described and there is growing evidence that these cells are involved in the pathogenesis of OSD. OSD is a complex term for a myriad of disorders that are often characterized by ocular surface inflammation, tear film instability and impairment of vision. Conclusions: This review summarizes the current knowledge concerning the immunotopographical distribution of APCs in the normal ocular surface. APCs appear to play a critical role in the pathology of a number of conditions associated with OSD including infectious keratitis, ocular allergy, dry eye disease and pterygium. © 2020, Springer Nature B.V.
Συγγραφείς:
Kalogeropoulos, D.
Papoudou-Bai, A.
Lane, M.
Goussia, A.
Charchanti, A.
Moschos, M.M.
Kanavaros, P.
Kalogeropoulos, C.
Περιοδικό:
International Ophthalmology
Λέξεις-κλειδιά:
antigen presenting cell; cell function; cell maturation; dry eye; eye allergy; human; Human alphaherpesvirus 1; immunopathogenesis; microbial keratitis; nonhuman; ocular surface disease; pterygium; Review; antigen presenting cell; cellular immunity; immunology; lacrimal fluid; metabolism; pathology, Antigen-Presenting Cells; Dry Eye Syndromes; Humans; Immunity, Cellular; Tears
DOI:
10.1007/s10792-020-01329-0
