Τίτλος:
The different faces of mycosis fungoides: results of a single-center study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Mycosis fungoides (MF) accounts for the majority of cutaneous lymphomas. Apart from the predominant Alibert-Bazin type, several clinicopathological variants of diverse prevalence and biological behavior have been described. Data on clinical and epidemiological aspects of MF clinical subtypes are still weak. Aim: To outline the clinical and epidemiological profile of the different MF types in a large volume of Greek patients. Methods: Retrospective analysis of 688 MF cases treated in our lymphoma clinic. Epidemiological, clinical, pathological, and immunohistochemical data were retrieved. Results: Six-hundred and thirty-six patients (416 males, 220 females) were included. The mean age at diagnosis was 60.2 years; the mean duration of disease prior to diagnosis was 63.2 months. Early-stage MF (I-IIA) involved 475 cases (74.7%). The prevalent type was classical MF (68.5%), followed by folliculotropic (17%), poikilodermic (5.5%), and psoriasiform (4.7%) MF. Atypical MF lesions as the sole manifestation of folliculotropic mycosis fungoides (FMF) – alopecia areata-like lesions (n = 10), keratosis pilaris-like lesions (n = 9) or acneiform rash (n = 4) – were also observed. Both poikilodermic and folliculotropic subtypes mainly involved younger patients. A significant diagnostic latency concerning poikilodermic and psoriasiform MF cases was recorded. Only 23 (3.3%) cases were of juvenile onset, with classical and poikilodermic MF equally affecting this age group, closely followed by FMF. Conclusions: Our study presents the whole clinical-epidemiological spectrum of MF in a large Greek cohort. The high prevalence of atypical MF manifestations characterized by early onset and indolent clinical course stood out among our FMF sample. © 2019 The International Society of Dermatology
Συγγραφείς:
Sidiropoulou, P.
Nikolaou, V.
Marinos, L.
Voudouri, D.
Komini, E.
Economidi, A.
Rigopoulos, D.
Stratigos, A.
Περιοδικό:
International Journal of Dermatology
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
adult; Article; cancer growth; cancer staging; classical mycosis fungoides; cohort analysis; controlled study; demography; disease duration; female; folliculotropic mycosis fungoides; follow up; human; human tissue; immunohistochemistry; incidence; major clinical study; male; mycosis fungoides; poikilodermic mycosis fungoides; prevalence; psoriasiform mycosis fungoides; retrospective study; skin biopsy; adolescent; aged; biopsy; child; Greece; middle aged; mycosis fungoides; pathology; preschool child; register; skin; skin tumor; young adult, Adolescent; Adult; Aged; Biopsy; Child; Child, Preschool; Female; Greece; Humans; Immunohistochemistry; Male; Middle Aged; Mycosis Fungoides; Prevalence; Registries; Retrospective Studies; Skin; Skin Neoplasms; Young Adult
