Τίτλος:
Impact of renin–angiotensin–aldosterone system polymorphisms on myocardial perfusion: Correlations with myocardial single photon emission computed tomography-derived parameters
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Renin–angiotensin–aldosterone system (RAAS) has an important role in atherosclerosis. We investigated the effects of six RAAS gene polymorphisms on myocardial perfusion. Methods and Results: We examined 810 patients with known or suspected coronary artery disease (CAD) using stress–rest myocardial single-photon emission computed tomography. Summed stress score (SSS), summed rest score (SRS), summed difference score (SDS), transient ischemic dilation (TID), and lung/heart ratio (LHR) were recorded. The following gene polymorphisms were investigated: angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensinogen (AGT) M235T and T174M, angiotensin II type 1 receptor (AT1R) A1166C, renin (REN) C5312T, and angiotensin II type 2 receptor (AT2R) C3123A. The heterozygotes or homozygotes on ACE D allele were 7.54 times more likely to have abnormal SSS, while the AGT (T174M) heterozygotes were 5.19 times more likely to have abnormal SSS. The homozygotes of ACE D had significantly higher values on TID and LHR, while the AGT (T174M) heterozygotes had higher values on TID. The AT1R heterozygotes had greater odds for having SSS ≥ 3. The patients carried AT1R homozygosity of C allele had significantly higher values on TID, while heterozygotes of AT1R had significantly higher values on LHR. Conclusions: Among the polymorphisms investigated, ACE D allele had the strongest association with abnormal myocardial perfusion. © 2018, American Society of Nuclear Cardiology.
Συγγραφείς:
Angelidis, G.
Samara, M.
Papathanassiou, M.
Satra, M.
Valotassiou, V.
Tsougos, I.
Psimadas, D.
Tzavara, C.
Alexiou, S.
Koutsikos, J.
Demakopoulos, N.
Giamouzis, G.
Triposkiadis, F.
Skoularigis, J.
Kollia, P.
Georgoulias, P.
Περιοδικό:
Journal of Nuclear Cardiology
Εκδότης:
Springer New York LLC
Λέξεις-κλειδιά:
angiotensin 1 receptor; angiotensin 2 receptor; angiotensinogen; beta adrenergic receptor blocking agent; calcium channel blocking agent; dipeptidyl carboxypeptidase; genomic DNA; nitric acid derivative; renin; tetrofosmin tc 99m; angiotensin receptor; angiotensinogen; dipeptidyl carboxypeptidase; renin, a1166c gene; adult; aged; allele; Article; c3123a gene; c5312t gene; cardiovascular parameters; cardiovascular risk; coronary artery disease; diabetes mellitus; DNA polymorphism; female; gated single photon emission computed tomography; gene; heart left ventricle enddiastolic volume; heart left ventricle endsystolic volume; heart muscle perfusion; heterozygote; homozygote; human; hyperlipidemia; hypertension; indel mutation; lung heart ratio; m235t gene; major clinical study; male; myocardial perfusion imaging; obesity; priority journal; renin angiotensin aldosterone system; scoring system; summed difference score; summed rest score; summed stress score; t174m gene; thorax pain; transient ischemic dilation; coronary artery blood flow; diagnostic imaging; genetic polymorphism; genetics; middle aged; myocardial perfusion imaging; pathophysiology; renin angiotensin aldosterone system; single photon emission computed tomography; very elderly, Adult; Aged; Aged, 80 and over; Angiotensinogen; Coronary Artery Disease; Coronary Circulation; Female; Humans; Male; Middle Aged; Myocardial Perfusion Imaging; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Tomography, Emission-Computed, Single-Photon
DOI:
10.1007/s12350-017-1181-8
