Τίτλος:
Proton Density Fat Suppressed MRI in 3T Increases the Sensitivity of Multiple Sclerosis Lesion Detection in the Cervical Spinal Cord
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: Considering the number of multiple sclerosis (MS) patients referred for clinical spinal cord imaging, the optimization of imaging protocols plays a crucial role. We aimed to evaluate the use of proton density (PD) turbo spin-echo (TSE) with spectral attenuated inversion recovery (SPAIR) fat suppression and compare it with the currently recommended T2-TSE-SPAIR in sagittal plane in cervical spinal cord imaging. Methods: In this study 35 MS patients with clinically suspected or known spinal cord lesions were scanned on a 3.0T magnetic resonance imaging (MRI) system. In addition to the routine protocol, PD-TSE-SPAIR sequences were obtained to quantitatively and qualitatively evaluate lesion detectability and image quality compared to T2-TSE-SPAIR sequences. Quantitative analysis was based on measurements of lesion-to-cord contrast ratio (LCCR), lesion contrast-to-noise ratio (LCNR) and lesion dimensions and the qualitative analysis on ranking with a predetermined score scale. The presence of lesions in these sequences was verified in axial T2 multi-echo gradient echo images. Results: In quantitative analysis, the lesions on PD-TSE-SPAIR had statistically significantly higher contrast (p < 0.05), according to the statistical test of LCCR, LCNR calculated contrast and measured lesion dimensions. Qualitative analyses were congruent with quantitative results; the median rank of PD-TSE-SPAIR was significantly higher than T2-TSE-SPAIR (p < 0.05). Of the 34 detected lesions 9 (26%) were not visualized in T2-TSE-SPAIR sequence. Conclusion: Considering its superiority in contrast ratios and lesion dimensions when compared to T2-TSE-SPAIR in both qualitative and quantitative analyses, we therefore recommend PD-TSE-SPAIR as a pivotal sequence to evaluate demyelinating spinal cord lesions at 3T. © 2017, Springer-Verlag GmbH Germany.
Συγγραφείς:
Karavasilis, E.
Velonakis, G.
Argiropoulos, G.
Athanasakos, A.
Poulou, L.S.
Toulas, P.
Kelekis, N.L.
Efstathopoulos, E.P.
Περιοδικό:
Clinical Neuroradiology
Εκδότης:
Urban und Vogel GmbH
Λέξεις-κλειδιά:
Article; cervical spinal cord injury; clinical article; contrast to noise ratio; human; image quality; lesion to cord contrast ratio; multiple sclerosis; nuclear magnetic resonance imaging; proton density fat suppressed nuclear magnetic resonance imaging; qualitative analysis; quantitative analysis; adult; comparative study; diagnostic imaging; evaluation study; female; male; multiple sclerosis; myelin sheath; nonparametric test; nuclear magnetic resonance imaging; procedures; sensitivity and specificity; signal noise ratio; spinal cord; spinal cord disease, Adult; Female; Humans; Magnetic Resonance Imaging; Male; Multiple Sclerosis; Myelin Sheath; Sensitivity and Specificity; Signal-To-Noise Ratio; Spinal Cord; Spinal Cord Diseases; Statistics, Nonparametric
DOI:
10.1007/s00062-017-0626-4
