Περίληψη:
Purpose:To stratify the literature on angioid streaks, from pathophysiology to treatment.Methods:Review of the current literature.Results:Angioid streaks are crack-like dehiscences of Bruch membrane, which may coexist with systemic diseases, such as pseudoxanthoma elasticum, Paget disease, Ehlers-Danlos syndrome, hemoglobinopathies, or other diseases of the collagen. Various diagnostic methods, including infrared and red-free retinography, autofluorescence, optical coherence tomography, fluorescein angiography, and indocyanine green angiography, are useful to diagnose, evaluate, and monitor angioid streaks. Choroidal neovascularization consists of a major complication of angioid streaks leading to visual impairment. Therefore, observation could not be a treatment option. Photodynamic treatment or anti-vascular endothelial growth factor agents have been used for the treatment of angioid streaks, offering promising but short-term results. Currently, the available treatment may limit the disease, but not permanently inactivate it.Conclusion:This review discusses the epidemiology, pathophysiology, diagnosis, and treatment of angioid streaks, presenting the existing literature on this topic. © 2020 Royal Society of Chemistry. All rights reserved.
Συγγραφείς:
Chatziralli, I.
Saitakis, G.
Dimitriou, E.
Chatzirallis, A.
Stoungioti, S.
Theodossiadis, G.
Theodossiadis, P.
Λέξεις-κλειδιά:
aflibercept; bevacizumab; ranibizumab; verteporfin; angiogenesis inhibitor, angioid streak; autofluorescence imaging; Bruch membrane; clinical feature; collagen disease; comorbidity; Ehlers Danlos syndrome; genetics; hemoglobinopathy; histopathology; human; indocyanine green angiography; inheritance; laser coagulation; optical coherence tomography; pathophysiology; photodynamic therapy; pseudoxanthoma elasticum; retina fluorescein angiography; retinography; Review; subretinal neovascularization; transpupillary thermotherapy; visual impairment; angioid streak; eye fundus; fluorescence angiography; global health; incidence; pathology; photochemotherapy; procedures; retina; visual acuity, Angiogenesis Inhibitors; Angioid Streaks; Fluorescein Angiography; Fundus Oculi; Global Health; Humans; Incidence; Photochemotherapy; Retina; Tomography, Optical Coherence; Visual Acuity
