Τίτλος:
The influence of treatment, age at onset, and metabolic control on height in children and adolescents with type 1 diabetes—A SWEET collaborative study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To describe the association between height, demographics, and treatment in youths with type 1 diabetes participating in an international network for pediatric diabetes centers (SWEET). Methods: Data were collected from 55 centers with documented patients' height. All subjects below 20 years of age, diabetes duration >1 year, and without celiac disease were included. World Health Organization growth charts were used to calculate height and body mass index z-scores. Multiple hierarchic regression models adjusting for known confounders were applied. Results: Data on 22 941 subjects (51.8% male) were analyzed with a median and interquartile range for age 14.8 years (11.2, 17.6), diabetes duration 5.6 years (3.1, 8.9), and height z-score 0.34 (−0.37, 1.03). Children were taller in the youngest age groups: adjusted height z-scores of 0.31 (±0.06) and 0.39 (±0.06), respectively; with shorter diabetes duration (<2 years: 0.36 [±0.06]; 2-<5 years: 0.34 [±0.06]; ≥5 years: 0.21 [±0.06]) and if they were pump users: 0.35 ± 0.05 vs 0.25 ± 0.05 (>three injections/day and 0.19 ± 0.06 [0-3 injections daily]), respectively. High hemoglobin A1c (HbA1c) and low to normal weight were associated with a lower height z-score. Trends were identical in all models except for gender. No gender differences were found except in the final height model where females exhibited higher z-score than males. Conclusion: For youths treated at centers offering modern diabetes management, major growth disturbances are virtually eliminated. For children with a young age at onset, high HbA1c, injections, and/or non-intensive diabetes, treatment still requires attention in order to attain normal growth. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Συγγραφείς:
Svensson, J.
Schwandt, A.
Pacaud, D.
Beltrand, J.
Birkebæk, N.H.
Cardona-Hernandez, R.
Casteels, K.
Castro, S.
Cherubini, V.
Cody, D.
Fisch, N.
Hasnani, D.
Kordonouri, O.
Kosteria, I.
Luczay, A.
Pundziute-Lyckå, A.
Maffeis, C.
Piccini, B.
Luxmi, P.
Sumnik, Z.
de Beaufort, C.
Περιοδικό:
Pediatric Diabetes
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
hemoglobin A1c; insulin; glycosylated hemoglobin; insulin, adolescent; adolescent health; adult; Article; body height; body mass; child; cross-sectional study; disease association; disease duration; female; groups by age; hemoglobin blood level; human; insulin dependent diabetes mellitus; intermethod comparison; major clinical study; male; metabolic regulation; onset age; preschool child; priority journal; school child; treatment outcome; young adult; child development; clinical trial; community care; cooperation; drug effect; factual database; glucose blood level; insulin dependent diabetes mellitus; insulin infusion; international cooperation; metabolism; multicenter study; onset age; organization and management; physiology, Adolescent; Age of Onset; Blood Glucose; Body Height; Child; Child Development; Community Networks; Cooperative Behavior; Cross-Sectional Studies; Databases, Factual; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin A; Humans; Insulin; Insulin Infusion Systems; International Cooperation; Male
