Τίτλος:
Links between HPA axis and adipokines: clinical implications in paradigms of stress-related disorders
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction: In the human organism, a constant interplay exists between the stress system [which includes the activity of the hypothalamic-pituitary-adrenal (HPA) axis] and the adipose tissue. This interplay is mediated by hormones of the HPA axis such as corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and glucocorticoids (GCs) and adipokines secreted by the adipose tissue. Areas covered: In this critical review, the bi-directional interactions between HPA axis and the most studied adipokines such as leptin and adiponectin, as well as the pro-inflammatory adipocytokines tumor necrosis factor (TNF) and interleukin (IL) 6 are presented. Furthermore, these interactions are described in normalcy as well as in specific clinical paradigms of stress-related disorders such as eating disorders, hypothalamic amenorrhea, and stress-related endogenous hypercortisolism states. Wherever new therapeutic strategies emerge, they are presented accordingly. Expert commentary: Additional research is needed to clarify the mechanisms involved in the interplay between the HPA axis and the adipose tissue. Research should be focused, in particular, on the development of new therapeutic means targeting dysfunctional adipose tissue in stress-related situations. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Papargyri, P.
Zapanti, E.
Salakos, N.
Papargyris, L.
Bargiota, A.
Mastorakos, G.
Περιοδικό:
Expert Review of Endocrinology and Metabolism
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
adipocytokine; adiponectin; alpha interferon; beta interferon; corticotropin; corticotropin releasing factor; glucocorticoid; interleukin 1; interleukin 12; interleukin 6; interleukin 8; leptin; tumor necrosis factor; adipocytokine, adipose tissue; adrenal gland; arcuate nucleus; circadian rhythm; corticotropin release; dorsomedial hypothalamic nucleus; eating disorder; food intake; genetic regulation; human; hypercortisolism; hypothalamic amenorrhea; hypothalamus hypophysis adrenal system; immunocompetent cell; mental disease; priority journal; Review; second cervical vertebra; stress; stress related disorder; transcription initiation; hypophysis adrenal system; hypothalamus hypophysis system; mental stress; pathophysiology; physiology, Adipokines; Adipose Tissue; Humans; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Stress, Psychological
DOI:
10.1080/17446651.2018.1543585
