Τίτλος:
Resolution of Hematocolpos in Adolescents Affected with Graft vs Host Disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Bone marrow transplantation is a lifesaving procedure for a range of serious benign or malignant hematological conditions. A proportion of patients, however, will develop graft vs host disease (GVHD), acute or chronic, with serious long-term sequalae. Cases: We present 2 cases of hematocolpos that developed in adolescence because of vaginal synechiae due to GVHD. The condition was initially asymptomatic, resolved spontaneously at first and recurred. In 1 girl blunt lysis of the adhesions was performed with the patient under general anesthesia, followed thereafter by local hydrocortisone and estriol treatment. Summary and Conclusion: Genital symptoms might not be readily reported by adolescents after bone marrow transplantation. Physicians should be aware of possible late effects of GVHD on genitalia, inquire about symptoms, and be acquainted with addressing complications, such as vaginal obstruction. © 2018 North American Society for Pediatric and Adolescent Gynecology
Συγγραφείς:
Michala, L.
Vlachopapadopoulou, E.
Tsimaris, P.
Papaioannou, G.
Paisiou, A.
Peristeri, I.
Michalacos, S.
Kitra, V.
Περιοδικό:
Journal of Pediatric and Adolescent Gynecology
Εκδότης:
ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Λέξεις-κλειδιά:
busulfan; cyclophosphamide; cyclosporine; estradiol valerate; estriol; fludarabine; hydrocortisone; melphalan; methotrexate; steroid; thymocyte antibody; estriol, adolescent; allogenic bone marrow transplantation; amenorrhea; Article; case report; chronic graft versus host disease; clinical article; drug dose increase; drug megadose; echography; Fanconi renotubular syndrome; female; female genital tract malformation; follow up; graft versus host reaction; hematocolpos; hormone substitution; human; hypergonadotropic hypogonadism; low drug dose; lower abdominal pain; myelodysplastic syndrome; priority journal; prophylaxis; steroid therapy; transplantation conditioning; vagina atrophy; vaginal synechiae; bone marrow transplantation; child; complication; graft versus host reaction; hematocolpos; male; nuclear magnetic resonance imaging; pathology; recurrent disease; tissue adhesion; vagina, Adolescent; Bone Marrow Transplantation; Child; Estriol; Female; Graft vs Host Disease; Hematocolpos; Humans; Magnetic Resonance Imaging; Male; Recurrence; Tissue Adhesions; Vagina
DOI:
10.1016/j.jpag.2018.05.006
