Τίτλος:
A literature review to evaluate the economic value of ranolazine for the symptomatic treatment of chronic angina pectoris
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
To conduct a systematic review of the evidence regarding the economic value of ranolazine relative to standard-of-care (SOC) for the treatment of symptomatic chronic stable angina (CSA). Electronic databases were searched using relevant keywords. The identified studies were independently reviewed by two investigators against pre-determined inclusion and exclusion criteria. Their data were extracted using a relevant form and consequently were synthesized. Studies were also evaluated using the Quality of Health Economic Studies scale. The main outcomes considered were the cost and effectiveness for each comparator and the incremental cost per quality-adjusted-life year (QALY) gained. Six studies were included in the review. Five of these assessed the cost-utility of ranolazine added to SOC, compared to SOC alone, using decision trees or Markov models whereas one was a retrospective cost evaluation study. The analysis was conducted from a payer perspective in five studies and from a societal perspective in one study with the time horizon varying between six months and a year. The incremental cost-effectiveness ratio (ICER), ranged from €4000 to €15,000 per QALY gained. Ranolazine appears to be dominant or cost-effective, mainly due to its ability to decrease angina-related hospitalizations and also due to a marginal improvement in quality of life. The acquisition cost of ranolazine was the variable with the greatest impact upon the ICER. The existing evidence, although limited, indicates that ranolazine may be a dominant or cost-effective therapy option, for the treatment of patients with symptomatic CSA. Further research is required to evaluate the cost-effectiveness of ranolazine. © 2016 Elsevier Ireland Ltd. All rights reserved.
Συγγραφείς:
Vellopoulou, K.
Kourlaba, G.
Maniadakis, N.
Vardas, P.
Περιοδικό:
International Journal of Cardiology
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
ranolazine; cardiovascular agent; ranolazine, angina pectoris; cost effectiveness analysis; cost utility analysis; decision tree; drug cost; economic evaluation; health care quality; hospitalization; human; medical decision making; medical research; priority journal; probability; quality adjusted life year; quality of life; retrospective study; Review; systematic review; treatment outcome; Angina, Stable; cost benefit analysis; economics; procedures, Angina, Stable; Cardiovascular Agents; Cost-Benefit Analysis; Humans; Ranolazine; Treatment Outcome
DOI:
10.1016/j.ijcard.2016.02.140
