Ερευνητικό υλικό ΕΚΠΑ

Solar insolation in springtime influences age of onset of bipolar I disorder

Αγγλικά

Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

2017

Bauer, M.
Glenn, T.
Alda, M.
Aleksandrovich, M.A.
Andreassen, O.A.
Angelopoulos, E.
Ardau, R.
Ayhan, Y.
Baethge, C.
Bharathram, S.R.
Bauer, R.
Baune, B.T.
Becerra-Palars, C.
Bellivier, F.
Belmaker, R.H.
Berk, M.
Bersudsky, Y.
Bicakci, Ş.
Birabwa-Oketcho, H.
Bjella, T.D.
Bossini, L.
Cabrera, J.
Cheung, E.Y.W.
Del Zompo, M.
Dodd, S.
Donix, M.
Etain, B.
Fagiolini, A.
Fountoulakis, K.N.
Frye, M.A.
Gonzalez-Pinto, A.
Gottlieb, J.F.
Grof, P.
Harima, H.
Henry, C.
Isometsä, E.T.
Janno, S.
Kapczinski, F.
Kardell, M.
Khaldi, S.
Kliwicki, S.
König, B.
Kot, T.L.
Krogh, R.
Kunz, M.
Lafer, B.
Landén, M.
Larsen, E.R.
Lewitzka, U.
Licht, R.W.
Lopez-Jaramillo, C.
MacQueen, G.
Manchia, M.
Marsh, W.
Martinez-Cengotitabengoa, M.
Melle, I.
Meza-Urzúa, F.
Yee Ming, M.
Monteith, S.
Morken, G.
Mosca, E.
Munoz, R.
Mythri, S.V.
Nacef, F.
Nadella, R.K.
Nery, F.G.
Nielsen, R.E.
O'Donovan, C.
Omrani, A.
Osher, Y.
Østermark Sørensen, H.
Ouali, U.
Pica Ruiz, Y.
Pilhatsch, M.
Pinna, M.
da Ponte, F.D.R.
Quiroz, D.
Ramesar, R.
Rasgon, N.
Reddy, M.S.
Reif, A.
Ritter, P.
Rybakowski, J.K.
Sagduyu, K.
Scippa, Â.M.
Severus, E.
Simhandl, C.
Stein, D.J.
Strejilevich, S.
Subramaniam, M.
Sulaiman, A.H.
Suominen, K.
Tagata, H.
Tatebayashi, Y.
Tondo, L.
Torrent, C.
Vaaler, A.E.
Veeh, J.
Vieta, E.
Viswanath, B.
Yoldi-Negrete, M.
Zetin, M.
Zgueb, Y.
Whybrow, P.C.

Acta Psychiatrica Scandinavica

Wiley-Blackwell Publishing Ltd

136

6

571-582

adult; Article; bipolar I disorder; cohort analysis; depression; family history; female; human; major clinical study; male; mania; Northern Hemisphere; onset age; priority journal; solar insolation; solar radiation; Southern Hemisphere; spring; adolescent; Africa; Asia; astronomy; Australia; bipolar disorder; electromagnetic radiation; Europe; international cooperation; middle aged; North America; onset age; season; South America; sunlight; young adult, Adolescent; Adult; Africa; Age of Onset; Asia; Australia; Bipolar Disorder; Electromagnetic Radiation; Europe; Female; Humans; Internationality; Male; Middle Aged; North America; Seasons; Solar System; South America; Sunlight; Young Adult

https://doi.org/10.1111/acps.12772

10.1111/acps.12772

https://pergamos.lib.uoa.gr/uoa/dl/object/3125629