Τίτλος:
Bone Quality Assessment as Measured by Trabecular Bone Score in Patients With End-Stage Renal Disease on Dialysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD) exhibit osteoporosis and increased fracture risk. Dual-energy X-ray absorptiometry scan measurements and calculation of fracture risk assessment toll score underestimate fracture risk in these patients and do not estimate bone quality. Trabecular bone score (TBS) has been recently proposed as an indirect measure of bone microarchitecture. In this study, we investigated alterations of bone quality in patients with ESRD on HD, using TBS. Fifty patients with ESRD on HD, with a mean age 62 years, and 52 healthy individuals matched for age, body mass index, and gender, were enrolled. All participants had a bone mineral density (BMD) measurement by dual-energy X-ray absorptiometry scan at the lumbar spine, femoral neck, total hip, and 1/3 radius. TBS was evaluated using TBS iNsight. Serum fetuin-A and plasma fibroblast growth factor-23 (FGF-23) (C-terminal) were also measured. Patients on dialysis had significantly lower BMD values at all skeletal sites measured. Plasma FGF-23 levels significantly increased and serum fetuin-Α significantly decreased in patients on dialysis compared with controls. TBS was significantly reduced in patients on dialysis compared with controls (1.11 ± 0.16 vs 1.30 ± 0.13, p < 0.001, respectively) independently of age; BMD; duration of dialysis; and serum levels of alkaline phosphatase, 25-OH-vitamin D, parathyroid hormone, fetuin-A, or plasma FGF-23. Patients on HD who were diagnosed with an osteoporotic vertebral fracture had numerically lower TBS values, albeit without reaching statistical significance, compared with patients on dialysis without a fracture (1.044 ± 0.151 vs 1.124 ± 0.173, respectively, p = 0.079). Bone microarchitecture, as assessed by TBS, is significantly altered in ESRD on patients on HD independently of BMD values and metabolic changes that reflect chronic kidney disease-mineral and bone disorder. © 2016 International Society for Clinical Densitometry
Συγγραφείς:
Yavropoulou, M.P.
Vaios, V.
Pikilidou, M.
Chryssogonidis, I.
Sachinidou, M.
Tournis, S.
Makris, K.
Kotsa, K.
Daniilidis, M.
Haritanti, A.
Liakopoulos, V.
Περιοδικό:
Journal of Clinical Densitometry
Εκδότης:
HANLEY & BELFUS-ELSEVIER INC
Λέξεις-κλειδιά:
alkaline phosphatase; calcifediol; fetuin A; fibroblast growth factor 23; parathyroid hormone; AHSG protein, human; fetuin A; fibroblast growth factor; fibroblast growth factor 23, adult; age; aged; alkaline phosphatase blood level; Article; bone density; bone microarchitecture; case control study; clinical article; controlled study; cross-sectional study; dual energy X ray absorptiometry; end stage renal disease; female; femoral neck; fragility fracture; hemodialysis; hip; human; lumbar spine; male; musculoskeletal disease assessment; parathyroid hormone blood level; priority journal; protein blood level; radius; spine fracture; trabecular bone; Trabecular Bone Score; treatment duration; vitamin blood level; blood; chronic kidney failure; diagnostic imaging; injuries; lumbar vertebra; metabolism; middle aged; pathophysiology; photon absorptiometry; trabecular bone; very elderly, Absorptiometry, Photon; Adult; Aged; Aged, 80 and over; alpha-2-HS-Glycoprotein; Bone Density; Cancellous Bone; Case-Control Studies; Cross-Sectional Studies; Female; Femur Neck; Fibroblast Growth Factors; Humans; Kidney Failure, Chronic; Lumbar Vertebrae; Male; Middle Aged; Osteoporotic Fractures; Radius; Renal Dialysis
DOI:
10.1016/j.jocd.2016.11.002
