Τίτλος:
Ranolazine for the prevention or treatment of atrial fibrillation: A systematic review
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The use of currently available antiarrhythmic drugs for atrial fibrillation is limited by their moderate efficacy and the considerable proarrhythmic risk. Ranolazine, an antianginal agent, has been reported to possess antiarrhythmic properties, resulting in a reduction of supraventricular and ventricular arrhythmias. We performed a systematic review of the clinical studies reporting the outcome of patients treated with ranolazine for the prevention or treatment of atrial fibrillation in various clinical settings. We searched PubMed and abstracts of major conferences for clinical studies using ranolazine, either alone or in combination with other antiarrhythmic agents for the prevention or treatment of atrial fibrillation. Ten relevant records were identified. These included both randomized trials and retrospective cohort studies concerning the use of ranolazine in different clinical settings; prevention of atrial fibrillation in patients with acute coronary syndrome, prevention as well as conversion of postoperative atrial fibrillation after coronary artery bypass grafting, conversion of recent-onset atrial fibrillation, sinus rhythm maintenance in drug-resistant recurrent atrial fibrillation and facilitation of electrical cardioversion in cardioversion-resistant patients. A beneficial, mostly modest effect of ranolazine was homogeneously reported in all clinical settings. There were no substantial proarrhythmic effects. No meta-analysis could be performed because for most of the clinical scenarios, there was only one study investigating the effect of ranolazine. Except for one large randomized trial, all the other studies were either relatively small randomized studies or retrospective cohort analyses, which in several cases lacked a control group. This systematic review indicates a modest beneficial effect of ranolazine administered for the prevention or treatment of atrial fibrillation across several clinical settings without substantial proarrhythmic risk. © 2014 Italian Federation of Cardiology.
Συγγραφείς:
Dagres, N.
Iliodromitis, E.K.
Lekakis, J.P.
Simitsis, P.
Karatzas, D.
Rallidis, L.S.
Simeonidou, E.
Anastasiou-Nana, M.
Περιοδικό:
Journal of cardiovascular medicine (Hagerstown, Md.)
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
amiodarone; placebo; ranolazine; acetanilide derivative; antiarrhythmic agent; piperazine derivative; ranolazine, acute coronary syndrome; cardiovascular risk; cardioversion; coronary artery bypass graft; drug dose reduction; elective surgery; electrocardiogram; heart atrium fibrillation; heart infarction prevention; heart left ventricle ejection fraction; heart left ventricle hypertrophy; heart ventricle tachycardia; human; kidney failure; loading drug dose; meta analysis (topic); non ST segment elevation myocardial infarction; outcome assessment; postoperative complication; randomized controlled trial (topic); review; sinus rhythm; systematic review; acute coronary syndrome; Atrial Fibrillation; complication; multimodality cancer therapy; recurrent disease, Acetanilides; Acute Coronary Syndrome; Anti-Arrhythmia Agents; Atrial Fibrillation; Combined Modality Therapy; Coronary Artery Bypass; Electric Countershock; Humans; Piperazines; Recurrence
DOI:
10.2459/JCM.0b013e328365b554
