Τίτλος:
Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To compare the effects of 2.5 mg letrozole with those of 1 mg anastrazole daily on the hormonal and semen profiles of a subset of infertile men with low T/E 2 ratios. Design: Prospective, nonrandomized study. Setting: Reproductive medicine clinic. Patient(s): The study group consisted of 29 infertile men with a low serum T/E 2 ratio (<10). Intervention(s): Patients were divided into two groups. Group A included 15 patients treated with 2.5 mg letrozole orally once daily for 6 months, and Group B consisted of 14 patients treated with 1 mg anastrazole orally every day for 6 months. Main Outcome Measure(s): Hormonal evaluation included measurement of serum FSH, LH, PRL, T, and E 2. In all sperm analyses pretreatment and posttreatment total motile sperm counts (ejaculate volume × concentration × motile fraction) were evaluated. Result(s): The use of aromatase inhibitors (either letrozole or anastrazole) in cases of infertile men with low T/E 2 ratios improved both hormonal and semen parameters. Conclusion(s): This study suggests that some men with severe oligospermia, low T levels, and normal gonadotropin concentration may have a treatable endocrinopathy. © 2012 American Society for Reproductive Medicine, Published by Elsevier Inc.
Συγγραφείς:
Gregoriou, O.
Bakas, P.
Grigoriadis, C.
Creatsa, M.
Hassiakos, D.
Creatsas, G.
Περιοδικό:
International Journal of Fertility and Sterility
Λέξεις-κλειδιά:
anastrozole; estradiol; follitropin; letrozole; luteinizing hormone; prolactin; testosterone, adult; article; clinical article; estrogen blood level; follitropin blood level; human; luteinizing hormone blood level; male; male infertility; priority journal; prolactin blood level; prospective study; semen analysis; spermatozoon count; spermatozoon motility; testosterone blood level; testosterone to estradiol ratio; urogenital system parameters, Adult; Aromatase Inhibitors; Estradiol; Hormones; Humans; Infertility, Male; Male; Nitriles; Organ Size; Semen Analysis; Testis; Testosterone; Triazoles
DOI:
10.1016/j.fertnstert.2012.04.005
