Τίτλος:
Impact of prehypertension on carotid artery intima-media thickening: Actual or masked?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Recent studies have reported that prehypertension is associated with increased values of common carotid artery intima-media thickness (CCA-IMT). The aim of this study was to assess the impact of daytime ambulatory blood pressure (BP) levels on the association of prehypertension with CCA intima-media thickening in prehypertensive subjects. Methods: A total of 807 subjects with office systolic BP < 140 and diastolic BP < 90 mmHg, underwent 24 h ambulatory BP (ABP) monitoring and carotid artery ultrasonographic measurements. The study population was divided into 3 groups according to office and daytime ABP levels: (1) normotensives: subjects with office BP < 120/80 mmHg and daytime ambulatory BP values within the normal range, (2) actual prehypertensives: individuals with office SBP (120-139 mmHg) and/or DBP (80-89 mmHg) and daytime ambulatory BP values within the normal range and (3) prehypertensives with masked hypertension (MH): patients with office SBP (120-139 mmHg) and/or DBP (80-89 mmHg) and elevated daytime ambulatory BP values. Results: Prehypertensive patients with MH had higher (p< 0.01) CCA-IMT values (0.712 mm; 95%CI: 0.698-0.725) than actual prehypertensives (0.649 mm; 95%CI: 0.641-0.656) and normotensives (0.655 mm; 95%CI: 0.641-0.670) even after adjustment for baseline characteristics. Normotensives and actual prehypertensives did not differ significantly regarding CCA-IMT values (p> 0.05). After adjusting for potential confounders, (including demographic characteristics, vascular risk factors, and office BP) prehypertension with MH was independently (p< 0.01) associated with a 0.06 mm increment in CCA-IMT (95%CI: 0.03-0.09). Conclusions: Patients with office BP levels in the prehypertensive range, who also have elevated daytime ABP levels, had higher CCA-IMT values than patients with prehypertension with normal daytime ABP values and normotensive individuals. © 2010 Elsevier Ireland Ltd.
Συγγραφείς:
Manios, E.
Michas, F.
Tsivgoulis, G.
Stamatelopoulos, K.
Tsagalis, G.
Koroboki, E.
Alexaki, E.
Papamichael, C.
Vemmos, K.
Zakopoulos, N.
Περιοδικό:
Atherosclerosis
Λέξεις-κλειδιά:
adult; artery intima proliferation; article; blood pressure monitoring; carotid artery; circadian rhythm; controlled study; diastolic blood pressure; Doppler echography; female; human; hypertension; major clinical study; male; prehypertension; priority journal; systolic blood pressure, Blood Pressure; Blood Pressure Monitoring, Ambulatory; Carotid Arteries; Diastole; Female; Humans; Hypertension; Male; Middle Aged; Models, Statistical; Prevalence; Systole; Tunica Intima; Tunica Media; Ultrasonography
DOI:
10.1016/j.atherosclerosis.2010.10.032
