Τίτλος:
Low lymphocyte ratio as a novel prognostic factor in acute heart failure: Results from the Pre-RELAX-AHF study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Previous studies have suggested that a lower lymphocyte ratio (Ly%) in the white blood cell (WBC) differential count is related to worse outcomes in patients with acute heart failure (AHF) and other cardiovascular disorders. Methods: In the Pre-RELAX-AHF study, 234 patients with AHF, systolic blood pressure >125 mm Hg and brain natriuretic peptide ≥350 pg/ml or equivalent were randomized to 1 of 4 intravenous doses of relaxin or placebo and followed up for 6 months following randomization. Complete blood count and differential were performed by a central laboratory at baseline and then daily to day 5 and on day 14. Results: The WBC count by itself was not associated with measures of disease severity or outcome, and patients with Ly% <13% had similar baseline characteristics to patients with Ly% >13%, except for a higher baseline WBC count, elevated baseline glucose, older age and higher rates of peripheral vascular disease. However, patients with Ly% <13% had less improvement of dyspnea, greater worsening of heart failure, longer length of initial hospital stay and fewer days alive and out of hospital. Statistical significance was reached for all-cause death by days 60 and 180 (hazard ratio = 1.11 per percent decrease, 95% confidence interval 1.03-1.19; p = 0.0048). Conclusions: Despite no association with any baseline characteristic known to strongly predict outcome in AHF, low Ly% is associated with less symptom relief and worse in-hospital and postdischarge clinical outcomes. Copyright © 2010 S. Karger AG, Basel.
Συγγραφείς:
Milo-Cotter, O.
Teerlink, J.R.
Metra, M.
Felker, G.M.
Ponikowski, P.
Voors, A.A.
Edwards, C.
Weatherley, B.D.
Greenberg, B.
Filippatos, G.
Unemori, E.
Teichman, S.L.
Cotter, G.
Περιοδικό:
Cardiology (Switzerland)
Λέξεις-κλειδιά:
brain natriuretic peptide; glucose; placebo; relaxin, acute heart failure; aged; article; controlled study; dyspnea; female; hospitalization; human; lymphocyte count; major clinical study; male; peripheral vascular disease; priority journal; prognosis; systolic blood pressure, Aged; Female; Heart Failure; Humans; Infusions, Intravenous; Lymphocyte Count; Male; Middle Aged; Prognosis; Relaxin
