Τίτλος:
Malignant progression of a pleomorphic xanthoastrocytoma in a child
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Pleomorphic xanthoastrocytoma (PXA) is a recently recognized rare cerebral neoplasm that predominately affects young patients. We report on the case of a 3-year-old boy who presented with a 2-week history of headaches and seizures. Radiological investigation revealed a lesion in the right parietal-occipital lobe. The lesion was excised and histology disclosed the presence of a PXA with anaplastic features. 1 year later follow-up magnetic resonance imaging (MRI) revealed tumor relapse. An MRI of the spine was also performed and demonstrated leptomeningeal dissemination. The patient underwent a second operation. Histology revealed that the presence of a malignant PXA with anaplastic features. The patient received radiotherapy and 9 months later on follow-up MRI a new tumor recurrence was noted. A third craniotomy was performed and the tumor removed. Histological examination revealed dedifferentiation to glioblastoma multiforme. The patient was referred to the oncology department and received chemotherapy with temozolamide. 8 months later the patient was stable without tumor recurrence. PXAs require close follow-up because of their unpredictable biological behaviour. © Georg Thieme Verlag KG Stuttgart · New York.
Συγγραφείς:
Alexiou, G.A.
Moschovi, M.
Stefanaki, K.
Prodromou, C.
Sfakianos, G.
Prodromou, N.
Περιοδικό:
Neuropediatrics
Λέξεις-κλειδιά:
temozolomide, anamnesis; article; brain cancer; cancer chemotherapy; cancer radiotherapy; case report; child; clinical feature; computer assisted tomography; craniotomy; disease course; follow up; glioblastoma; histopathology; human; human tissue; male; nuclear magnetic resonance imaging; pleomorphic xanthoastrocytoma; preschool child; priority journal; tumor recurrence, Astrocytoma; Brain Neoplasms; Child, Preschool; Disease Progression; Gadolinium; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Tomography, X-Ray Computed
DOI:
10.1055/s-0030-1255094
