Τίτλος:
Polymorphisms of Renin-Angiotensin System and Natriuretic Peptide Receptor A Genes in Patients of Greek Origin with a History of Myocardial Infarction
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We assessed the association between (CA)n repeat polymorphism of angiotensinogen (AGT), 250 base pair (bp) insertion/deletion (I/D) of angiotensin-converting enzyme (ACE), tetranucleotide repeat polymorphism (TCTG)n of renin (REN), (CT)n repeat polymorphism of the natriuretic peptide receptor A (NPRA) genes, and the presence and extent of coronary artery disease (CAD) in Greek patients with a history of myocardial infarction (MI). A total of 158 post-MI patients referred for coronary angiography were compared with 144 controls. The SS genotype of the AGT gene was related with an increased risk for 3-vessel CAD (odds ratio [OR], 1.94; 95% confidence interval [CI], 1.05-3.61; P =.041), whereas the SL genotype was related with a decreased risk (OR, 0.44; 95% CI, 0.22-0.87; P =.019). Moreover, there was a trend for the SL genotype of the REN gene toward increased risk for CAD. There was a significant association between (CA)n polymorphism of the AGT gene and the extent of CAD in Greek patients with a history of MI. © 2010, SAGE Publications. All rights reserved.
Συγγραφείς:
Karayannis, G.
Tsezou, A.
Giannatou, E.
Papanikolaou, V.
Giamouzis, G.
Triposkiadis, F.
Περιοδικό:
International Angiology
Λέξεις-κλειδιά:
angiotensinogen; atrial natriuretic factor receptor; dipeptidyl carboxypeptidase; natriuretic peptide receptor A; renin, aged; article; coronary artery disease; female; genetic polymorphism; genetics; Greece; heart infarction; human; male, Aged; Angiotensinogen; Coronary Artery Disease; Female; Greece; Humans; Male; Myocardial Infarction; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Receptors, Atrial Natriuretic Factor; Renin
DOI:
10.1177/0003319710373091
