Τίτλος:
High-sensitivity CRP is correlated with neurologic symptoms and plaque instability in patients with severe stenosis of the carotid bifurcation
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of this study is to investigate the correlation of high-sensitivity C-reactive protein and E-selectin with clinical manifestations and plaque characteristics in 88 patients (69 with and 19 without neurological symptoms) with high-grade stenosis of the carotid bifurcation who underwent endarterectomy. The grade of stenosis was quantified by duplex ultrasonography and digital subtraction angiography. Preoperatively, serum high-sensitivity C-reactive protein and E-selectin were measured. Postoperatively, carotid plaque morphology was established according to the American Heart Association classification. High-sensitivity C-reactive protein levels were significantly (P <.001) higher in symptomatic than in asymptomatic patients, as well as in patients with unstable compared with those with stable plaques (P <.001). Serum high-sensitivity C-reactive protein levels correlated significantly ( P <.05) with macrophage count on the plaque. In conclusion, serum high-sensitivity C-reactive protein levels are associated with presence of neurological symptoms and plaque instability in patients with high-grade stenosis of the carotid bifurcation. © 2008 Sage Publications.
Συγγραφείς:
Papas, T.T.
Maltezos, C.K.
Papanas, N.
Kopadis, G.
Marakis, J.
Maltezos, E.
Bastounis, E.
Περιοδικό:
Italian Journal of Vascular and Endovascular Surgery
Λέξεις-κλειδιά:
C reactive protein; endothelial leukocyte adhesion molecule 1, adult; article; atherosclerotic plaque; cardiovascular risk; carotid artery bifurcation; carotid artery obstruction; clinical feature; digital subtraction angiography; disease association; echography; endarterectomy; female; human; inflammation; macrophage; major clinical study; male; neurologic disease; protein blood level, Aged; Angiography, Digital Subtraction; Biological Markers; C-Reactive Protein; Carotid Stenosis; E-Selectin; Endarterectomy, Carotid; Female; Humans; Ischemic Attack, Transient; Macrophages; Male; Middle Aged; Predictive Value of Tests; Severity of Illness Index; Stroke; Ultrasonography, Doppler, Duplex
DOI:
10.1177/1538574408314437
