Τίτλος:
Effect of the portacaval shunt on reperfusion injury after 65% hepatectomy in pigs
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Portal flow diversion by portacaval shunts (PCS) has been shown to prevent primary graft nonfunction in liver transplantation using small-for-size grafts. In this study, we examine whether PCS can improve reperfusion injury after major hepatectomy in pigs. Materials and Methods: In 14 pigs, a partial PCS was constructed following 65% hepatectomy and 1 h of inflow ischemia. During 24 h of reperfusion, the shunt was either closed (group A, n = 7) or left open (group B, n = 7). Results: 24 h after reperfusion, group A had higher levels of alanine aminotransferase (70 ± 12 IU/l vs. 51 ± 5.9 IU/l; p < 0.05), alanine aminotransferase per gram of liver remnant (0.41 ± 0.07 IU/l/g vs. 0.21 ± 0.05 IU/l/g; p < 0.05), prothrombin time (24.1 ± 2.4 s vs. 14.3 ± 2.9 s; p < 0.05), international normalized ratio (2.11 ± 0.15 vs. 1.29 ± 0.28; p < 0.05), hepatocyte necrosis scores and percentages of nuclei stained for proliferating cell nuclear antigen (52.57 ± 8.9% vs. 36.71 ± 6%; p < 0.05) compared to group B. Conclusions: Partial portal flow diversion appears to attenuate reperfusion injury in a porcine model of major hepatectomy. Copyright © 2008 S. Karger AG.
Συγγραφείς:
Farantos, C.
Arkadopoulos, N.
Theodoraki, K.
Kostopanagiotou, G.
Katis, K.
Tzavara, K.
Andreadou, I.
Dimopoulou, K.
Hatzoudi, E.
Sidiropoulou, T.
Skalkidis, I.
Paphiti, A.
Smyrniotis, V.
Περιοδικό:
European Surgical Research
Λέξεις-κλειδιά:
alanine aminotransferase; cycline, alanine aminotransferase blood level; animal experiment; animal model; animal tissue; article; liver injury; liver necrosis; liver resection; nonhuman; portal vein blood flow; portocaval shunt; priority journal; prothrombin time; staining, Animals; Hepatectomy; Liver; Portacaval Shunt, Surgical; Random Allocation; Reperfusion Injury; Swine; Warm Ischemia
