Τίτλος:
Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To investigate the response to controlled ovarian hyperstimulation and ART outcomes in women with advanced-stage endometriosis and previous surgeries at the Yale IVF program between 1996 and 2002. Design: Retrospective case control study. Setting: Academic medical center. Patient(s): The study group consisted of 68 women who previously undergone laparoscopic surgery for advanced-stage endometriosis. The control group included 106 women with tubal-factor infertility. The women with endometriosis underwent 133 IVF-ET cycles and the control group 208 cycles. Intervention(s): Controlled ovarian hyperstimulation and IVF-ET. Main Outcome Measure(s): Response to gonadotropins, fertilization, cleavage, implantation, pregnancy, miscarriage, and live birth rates. Result(s): Lower peak E2 levels, higher total gonadotropin requirements, lower oocyte yield, and higher cancellation rates were found in women with endometriosis compared with tubal-factor control subjects. However, no differences were found in fertilization, cleavage, implantation, pregnancy, miscarriage, and delivery rates between the endometriosis and tubal-factor groups. Conclusion(s): Women with advanced-stage endometriosis who have undergone previous surgery respond less well to gonadotropins than women with tubal-factor infertility. However, implantation, pregnancy, and delivery rates are similar, suggesting that embryo quality and uterine receptivity remains unaffected despite diminished ovarian reserve in women with endometriosis. © 2007 American Society for Reproductive Medicine.
Συγγραφείς:
Matalliotakis, I.M.
Cakmak, H.
Mahutte, N.
Fragouli, Y.
Arici, A.
Sakkas, D.
Περιοδικό:
International Journal of Fertility and Sterility
Λέξεις-κλειδιά:
chorionic gonadotropin; gonadotropin; human menopausal gonadotropin; leuprorelin; prostaglandin E2; urofollitropin, adult; article; birth rate; case control study; controlled study; disease course; endometriosis; female; fertilization; fertilization in vitro; hormonal therapy; human; infertility; laparoscopic surgery; live birth; major clinical study; nidation; oocyte; ovary hyperstimulation; pregnancy; priority journal; prostaglandin blood level; retrospective study; spontaneous abortion; uterine tube, Adult; Case-Control Studies; Delivery, Obstetric; Embryo Implantation; Endometriosis; Female; Fertilization in Vitro; Gonadotropins; Humans; Infertility, Female; Ovulation Induction; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Retrospective Studies; Treatment Outcome
DOI:
10.1016/j.fertnstert.2007.01.037
