Τίτλος:
Evidence of improved serum fatty acid profile of postmenopausal women receiving atorvastatin and raloxifene
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Raloxifene and atorvastatin have been shown to reduce the risk of cardiovascular disease associated with postmenopausal status and it has been postulated that their effects may be partly mediated by favourable changes in serum lipids and fatty acid composition. In the present study, individual administration of either raloxifene (Group A) or atorvastatin (Group B) or both (Group C) was compared for a period of 3 months and their effects on total lipids and fatty acids composition was evaluated. Postmenopausal women receiving both raloxifene and atorvastatin showed significant changes in the majority of serum lipids with important reductions in total cholesterol (p < 0.001), triglycerides (p < 0.001), LDL-C (p < 0.001) and Apo B levels (p < 0.001). Phospholipids concentrations (p < 0.01) as well as Apo A-I were also significantly raised (p < 0.001). Furthermore, oleic acid (18:1) and linoleic acid (18:2) levels were significantly increased (p < 0.01 and p < 0.001 respectively) followed by a marked reduction in palmitic acid (16:0) and arachidonic acid (20:4) concentrations (p < 0.01 and p < 0.001 respectively). The results of the study indicate that the serum lipid and fatty acid composition in postmenopausal women is influenced by the combined treatment of raloxifene and atorvastatin and a further attempt to evaluate the significance of these results is discussed. © 2005 Taylor & Francis.
Συγγραφείς:
Piperi, C.
Zisaki, K.
Skenderi, K.
Kalofoutis, C.
Kalofoutis, A.
Περιοδικό:
The journal of obstetrics and gynaecology research
Λέξεις-κλειδιά:
apolipoprotein A1; apolipoprotein B; arachidonic acid; atorvastatin; cholesterol; fatty acid; linoleic acid; lipid; low density lipoprotein cholesterol; oleic acid; palmitic acid; phospholipid; raloxifene; triacylglycerol, adult; aged; article; cholesterol blood level; comparative study; controlled study; fatty acid blood level; female; human; lipid blood level; lipid composition; major clinical study; phospholipid blood level; postmenopause; priority journal; triacylglycerol blood level, Adult; Aged; Anticholesteremic Agents; Cardiovascular Diseases; Drug Therapy, Combination; Fatty Acids; Female; Heptanoic Acids; Humans; Middle Aged; Postmenopause; Pyrroles; Raloxifene; Risk; Treatment Outcome
DOI:
10.1080/01443610500171060
