Περίληψη:
Acrylamide exposure was investigated in subgroups of the EPIC study
population (510 subjects from 9 European countries, randomly selected
and stratified by age, gender, and smoking status) using hemoglobin
adducts of acrylamide (HbAA) and its primary metabolite glycidamide
(HbGA). Blood samples were analyzed for HbAA and HbGA by HPLC/MS/MS.
Statistical models for HbAA and HbGA were developed including body mass
index (BMI), educational level, and physical activity. A large
variability in acrylamide exposure and metabolism between individuals
and country groups was observed with HbAA and HbGA values ranging
between 15-623 and 8-377 pmol/g of Hb, respectively. Both adducts
differed significantly by country, sex, and smoking status. HbGA values
were significantly lower in high alcohol consumers than in moderate
consumers. With increasing BMI, HbGA in nonsmokers and HbAA in smokers
decreased significantly. In the assessment of potential health effects
related to acrylamide exposure, country of origin, BMI, alcohol
consumption, sex, and smoking status should be considered.
Συγγραφείς:
Vesper, Hubert W.
Slimani, Nadia
Hallmans, Goran
Tjonneland,
Anne
Agudo, Antonio
Benetou, Vassiliki
Bingham, Sheila and
Boeing, Heiner
Boutron-Ruault, Marie-Christine and
Bueno-de-Mesquita, H. Bas
Chirlaque, Dolores
Clavel-Chapelon,
Francoise
Crowe, Francesca
Drogan, Dagmar
Ferrari, Pietro
and Johansson, Ingegerd
Kaaks, Rudolf
Linseisen, Jakob
Lund,
Eiliv
Manjer, Jonas
Mattiello, Amalia
Palli, Domenico and
Peeters, Petra H. M.
Rinaldi, Sabina
Skeie, Guri and
Trichopoulou, Antonia
Vineis, Paolo
Wirfalt, Elisabet and
Overvad, Kim
Stromberg, Ulf
