Τίτλος:
Caffeine challenge and breath-holding duration in patients with panic
disorder
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: Breath-holding (BH) has been used as a simple probe to
increase endogenous carbon dioxide (CO2). In patients with Panic
Disorder (PD), lower baseline BH duration is associated with
caffeine-induced panic attacks. In this paper, we assessed BH duration
in PD patients in relation to panic attacks induced by caffeine intake.
Methods: BH duration and state anxiety were assessed in 40 PD patients
(12 males), both at baseline and after a 400-mg caffeine challenge test.
Results: Patients panicking after caffeine administration (14 patients,
4 males) exhibited a significant reduction of their post-challenge BH
duration, while no change of the BH duration was observed in
non-panicking patients (26 patients, 8 males), Reduction in
post-challenge BH duration was not related to higher anxiety levels - as
reflected in the State-Trait Anxiety Inventory-State Form scores -
independently of the occurrence of a panic attack. Panickers exhibited
significantly lower baseline BH duration, compared to non-panickers.
Conclusions: Our findings indicate that in PD patients, caffeine-induced
panic attacks are strongly associated with a significant reduction of BH
duration at both pre- and post-challenge. jointly, these findings
suggest that in a Subgroup of PD patients, sensitivity to endogenous CO2
accumulation may underlie both the lower BH durations and the
caffeine-induced panic attacks. In this subgroup of PD patients,
caffeine might exert its panicogenic properties through the exacerbation
of patients’ already pathological hypersensitivity to CO2 accumulation,
as indicated by both the significant decrease of their BH duration at
post-challenge and by their significantly lower baseline BH duration
respectively. (c) 2008 Elsevier Inc. All rights reserved.
Συγγραφείς:
Masdrakis, Vasihos G.
Markianos, Manolis
Vaidakis, Nikolaos and
Papakostas, Yiannis G.
Oulis, Panagiotis
Περιοδικό:
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Εκδότης:
PERGAMON-ELSEVIER SCIENCE LTD
Λέξεις-κλειδιά:
Breath-holding duration; Caffeine challenge test; Panic disorder
DOI:
10.1016/j.pnpbp.2008.10.002
