Περίληψη:
Many case-control studies have suggested that higher consumption of
fruit and vegetables is associated with a lower risk or pancreatic
cancer, whereas cohort studies do not support such an association. We
examined the associations of the consumption of. fruits and vegetables
and their main subgroups with pancreatic cancer risk within the European
Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is
comprised of over 520,000 Subjects recruited from 10 European countries.
The present study included 555 exocrine pancreatic cancer cases after an
average follow-up of 8.9 years. Estimates of risk were obtained by Cox
proportional hazard models, stratified by age at recruitment, gender,
and study center. and adjusted for total energy intake, weight, height,
history of diabetes mellitus, and smoking status. Total consumption of
fruit and vegetables, combined or separately, as well as subgroups of
vegetables and fruits were unrelated to risk of pancreatic cancer.
Hazard ratios (95% CI) for the highest versus the lowest quartile were
0.92 (0.68-1.25) for total fruit and vegetables combined, 0.99
(0.73-1.33) for total vegetables, and 1.02 (0.77-1.36) for total fruits.
Stratification by gender or smoking status, restriction to
microscopically verified cases, and exclusion of the first 2 years of
follow-up (lid not materially change the results. These results from a
large European prospective cohort Suggest that higher consumption of
fruit and vegetables is not associated with decreased risk of pancreatic
cancer. (C) 2008 Wiley-Liss, Inc.
Συγγραφείς:
Vrieling, Alina
Verhage, Bas A. J.
van Duijnhoven, Franzel J. B.
and Jenab, Mazda
Overvad, Kim
Tjonneland, Anne
Olsen, Anja
and Clavel-Chapelon, Francoise
Boutron-Ruault, Marie-Christine and
Kaaks, Rudolf
Rohrmann, Sabine
Boeing, Heiner
Noethlings,
Ute
Trichopoulou, Antonia
John, Tountas
Dimosthenes, Zilis
and Palli, Domenico
Sieri, Sabina
Mattielllo, Amalia
Tumino,
Rosario
Vineis, Paolo
van Gils, Carla H.
Peeters, Petra H.
M.
Engeset, Dagrun
Lund, Eiliv
Rodriguez Suarez, Laudina and
Jakszyn, Paula
Larranaga, Nerea
Sanchez, Maria-Jose and
Chirlaque, Maria-Dolores
Ardana, Eva
Manjer, Jonas and
Lindkvist, Bjoern
Hallmans, Goeran
Ye, Weimin
Bingham,
Sheila
Khaw, Kay-Tee
Roddam, Andrew
Key, Tim
Boffetta,
Paolo
Duell, Eric J.
Michaud, Dominique S.
Riboli, Elio and
Bueno-de-Mesquita, H. Bas
