Περίληψη:
Introduction: Increased levels of interleukin 6 (IL-6), a marker for
systemic inflammation, have been associated with cardiovascular
morbidity and mortality.
Materials and Methods: We investigated the influence of IL6 gene
polymorphisms on mean level and variability of plasma IL-6 in a
population of myocardial infarction survivors recruited in six European
cities as part of the AIRGENE study. DNA from each individual was
collected and genotyped for eight functional and tagging single
nucleotide polymorphisms (SNPs) in the IL6 gene.
Results: We analyzed 946 subjects with 5520 repeated plasma samples for
IL-6 levels. For four IL6 SNPs in high linkage disequilibrium,
heterozygous and homozygous minor allele genotypes were associated with
an increase in mean plasma IL-6 levels. SNP rs1800795 was associated
with a 6.3% increase in IL-6 (95% confidence interval [CI]
1.7-11.2%) For these SNPs, we found that genotypes associated with
higher IL-6 levels also tended to be associated to higher
between-individual variability of IL-6 levels on the log-scale than
other genotypes. Variability over time within individuals varied little
by genotype.
Conclusions: We found four genetic polymorphisms in the IL6 gene
associated with mean level and variability of plasma IL-6 between
individuals in myocardial infarction survivors. (C) 2008 Elsevier Ltd.
All rights reserved.
Συγγραφείς:
Ljungman, Petter
Bellander, Tom
Nyberg, Fredrik
Lampa, Erik
and Jacquemin, Benedicte
Kolz, Melanie
Lanki, Timo and
Mitropoulos, John
Muller, Martina
Picciotto, Sally
Pistelli,
Riccardo
Rucker, Regina
Koenig, Wolfgang
Peters, Annette and
AIRGENE Study Grp
