Περίληψη:
We examined the associations of measured anthropometric factors,
including general and central adiposity and height, with ovarian cancer
risk. We also investigated these associations by menopausal status and
for specific histological subtypes. Among 226,798 women in the European
Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there
were 611 incident cases of primary, malignant, epithelial ovarian cancer
diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards
models were used to estimate hazard ratios (HRs) and 95% confidence
intervals (as), adjusted for potential confounders. Compared to women
with body mass index (BMI) < 25 kg/m(2), obesity (BMI >= 30 kg/m(2)) was
associated with excess ovarian cancer risk for all women combined (HR =
1.33, 95% Cl = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR
= 1.59, 95% Cl = 1.20-2.10; p(trend) = 0.001), but the association was
weaker for premenopausal women (HR = 1.16, 95% Cl = 0.65-2.06; p(trend)
= 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat
distribution assessed by waist circumference, waist-hip ratio (WHR) or
hip circumference were associated with overall risk. WHR was related to
increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit
increment = 1.17, 95% Cl = 1.00-1.38). For all women combined, no other
significant associations with risk were observed for specific
histological subtypes. This large, prospective study provides evidence
that obesity is an important modifiable risk factor for epithelial
ovarian cancer, particularly among postmenopausal women.
Συγγραφείς:
Lahmann, Petra H.
Cust, Anne E.
Friedenreich, Christine M. and
Schulz, Mandy
Lukanova, Annekatrin
Kaaks, Rudolf
Lundin, Eva
and Tjonneland, Anne
Halkjaer, Jytte
Severinsen, Marianne Tang
and Overvad, Kim
Fournier, Agnes
Chabbert-Buffet, Nathalie and
Clavel-Chapelon, Francoise
Dossus, Laure
Pischon, Tobias and
Boeing, Heiner
Trichopoulou, Antonia
Lagiou, Pagona
Naska,
Androniki
Palli, Domenico
Grioni, Sara
Mattiello, Amalia and
Tumino, Rosario
Sacerdote, Carlotta
Redondo, Maria-Luisa and
Jakszyn, Paula
Sanchez, Maria-Jose
Tormo, Maria-Jose and
Ardanaz, Eva
Arriola, Larraitz
Manjer, Jonas
Jirstrom, Karin
and Bueno-de-Mesquita, H. Bas
May, Anne M.
Peeters, Petra H. M.
and Onland-Moret, N. Charlotte
Bingham, Sheila
Khaw, Kay-Tee and
Allen, Naomi E.
Spencer, Elizabeth
Rinaldi, Sabina
Slimani,
Nadia
Chajes, Veronique
Michaud, Dominique
Norat, Teresa and
Riboli, Elio
