Περίληψη:
Background: Epidemiologic data and animal models suggest that, despite
the predominant role of human papillomavirus infection, sex steroid
hormones are also involved in the etiology of invasive cervical
carcinoma (ICC).
Methods: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia
grade 3 (CIN3) cases and 2 control women matched with each case for
center, age, menopausal status and blood collection-related variables,
were identified in the European Prospective Investigation into Cancer
and Nutrition (EPIC) study. Circulating levels of testosterone (T) and
estradiol (E-2); dehydroepiandrosterone sulfate (DHEAS); progesterone
(premenopausal women); and sex hormone-binding globulin (SHBG) were
measured using immunoassays. Levels of free (f) T and E-2 were
calculated from absolute concentrations of T, E-2, and SHBG. Odds ratios
(ORs) and 95% confidence intervals (CI) were computed using regularized
conditional logistic regression.
Results: Among premenopausal women, associations with ICC were observed
for fT (OR for highest vs. lowest tertile 5.16, 95% CI, 1.50-20.1).
SHBG level was associated with a significant downward trend in ICC risk.
T, E-2, fE(2), and DHEAS showed nonsignificant positive association with
ICC. Progesterone was uninfluential. Among postmenopausal women,
associations with ICC were found for T (OR 3.14; 95% CI, 1.21-9.37),
whereas E-2 and fT showed nonsignificant positive association. SHBG
level was unrelated to ICC risk in postmenopausal women. No associations
between any hormone and CIN3 were detected in either pre- or
postmenopausal women.
Conclusions: Our findings suggest for the first time that T and possibly
E-2 may be involved in the etiology of ICC.
Impact: The responsiveness of cervical tumors to hormone modulators is
worth exploring. Cancer Epidemiol Biomarkers Prev; 20(12); 2532-40. (C)
2011 AACR.
Συγγραφείς:
Rinaldi, Sabina
Plummer, Martyn
Biessy, Carine
Castellsague,
Xavier
Overvad, Kim
Kjaer, Susanne Krueger
Tjonneland, Anne
and Clavel-Chapelon, Francoise
Chabbert-Buffet, Nathalie and
Mesrine, Sylvie
Lukanova, Annekatrin
Kaaks, Rudolf
Weikert,
Cornelia
Boeing, Heiner
Trichopoulou, Antonia
Lagiou, Pagona
and Trichopoulos, Dimitrios
Palli, Domenico
Agnoli, Claudia and
Tumino, Rosario
Vineis, Paolo
Panico, Salvatore and
Bueno-de-Mesquita, Bas
van Kranen, Henk J.
Peeters, Petra H. M.
and Bakken, Kjersti
Lund, Eiliv
Gram, Inger Torhild and
Rodriguez, Laudina
Bosch, F. Xavier
Sanchez, Maria-Jose and
Dorronsoro, Miren
Navarro, Carmen
Barricarte Gurrea, Aurelio and
Kjellberg, Lennart
Dillner, Joakim
Manjer, Jonas
Butt, Salma
and Khaw, Kay-Tee
Wareham, Nicholas
Allen, Naomi E.
Travis,
Ruth
Romieu, Isabelle
Ferrari, Pietro
Riboli, Elio and
Franceschi, Silvia
