Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation to pancreatic cancer risk: a study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3151567 47 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation
to pancreatic cancer risk: a study within the European Prospective
Investigation into Cancer and Nutrition (EPIC) cohort
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aims/hypothesis There has been long-standing debate about whether
diabetes is a causal risk factor for pancreatic cancer or a consequence
of tumour development. Prospective epidemiological studies have shown
variable relationships between pancreatic cancer risk and blood markers
of glucose and insulin metabolism, overall and as a function of lag
times between marker measurements (blood donation) and date of tumour
diagnosis.
Methods Pre-diagnostic levels of HbA(1c) and C-peptide were measured for
466 participants with pancreatic cancer and 466 individually matched
controls within the European Prospective Investigation into Cancer and
Nutrition. Conditional logistic regression models were used to estimate
ORs for pancreatic cancer.
Results Pancreatic cancer risk gradually increased with increasing
pre-diagnostic HbA(1c) levels up to an OR of 2.42 (95% CI 1.33, 4.39
highest [>= 6.5%, 48 mmol/mol] vs lowest [<= 5.4%, 36 mmol/mol]
category), even for individuals with HbA(1c) levels within the
non-diabetic range. C-peptide levels showed no significant relationship
with pancreatic cancer risk, irrespective of fasting status. Analyses
showed no clear trends towards increasing hyperglycaemia (as marked by
HbA(1c) levels) or reduced pancreatic beta cell responsiveness (as
marked by C-peptide levels) with decreasing time intervals from blood
donation to cancer diagnosis.
Conclusions/interpretation Our data on HbA(1c) show that individuals who
develop exocrine pancreatic cancer tend to have moderate increases in
HbA(1c) levels, relatively independently of obesity and insulin
resistance-the classic and major risk factors for type 2 diabetes. While
there is no strong difference by lag time, more data are needed on this
in order to reach a firm conclusion.
Έτος δημοσίευσης:
2011
Συγγραφείς:
Grote, V. A.
Rohrmann, S.
Nieters, A.
Dossus, L. and
Tjonneland, A.
Halkjaer, J.
Overvad, K.
Fagherazzi, G. and
Boutron-Ruault, M. C.
Morois, S.
Teucher, B.
Becker, S. and
Sluik, D.
Boeing, H.
Trichopoulou, A.
Lagiou, P. and
Trichopoulos, D.
Palli, D.
Pala, V.
Tumino, R.
Vineis,
P.
Panico, S.
Rodriguez, L.
Duell, E. J.
Molina-Montes,
E.
Dorronsoro, M.
Huerta, J. M.
Ardanaz, E.
Jeurnink, S.
M.
Beulens, J. W. J.
Peeters, P. H. M.
Sund, M.
Ye, W.
and Lindkvist, B.
Johansen, D.
Khaw, K. T.
Wareham, N. and
Allen, N.
Crowe, F.
Jenab, M.
Romieu, I.
Michaud, D. S.
and Riboli, E.
Romaguera, D.
Bueno-de-Mesquita, H. B.
Kaaks,
R.
Περιοδικό:
Diabetologia
Εκδότης:
Springer-Verlag
Τόμος:
54
Αριθμός / τεύχος:
12
Σελίδες:
3037-3046
Λέξεις-κλειδιά:
C-peptide; HbA(1c); Cohort study; Diabetes; EPIC; Pancreatic cancer
Επίσημο URL (Εκδότης):
DOI:
10.1007/s00125-011-2316-0
Το ψηφιακό υλικό του τεκμηρίου δεν είναι διαθέσιμο.