Τίτλος:
TGF-beta signalling in colon carcinogenesis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Colorectal cancer remains the most common cancer and the second leading
cause of cancer mortality in Europe. There are a number of pathways that
have been implicated in colorectal carcinogenesis, including TGF-beta
(TGF-beta)/Smad signalling pathway. The TGF-beta pathway is involved in
several biological processes, including cell proliferation,
differentiation, migration and apoptosis. Here we review the role of
TGF-beta signalling cascade in colorectal carcinogenesis and provide
some new molecular insights that may aid efforts towards targeted
antitumor therapies. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Συγγραφείς:
Lampropoulos, Pavlos
Zizi-Sermpetzoglou, Adamantia
Rizos, Spyros
and Kostakis, Alkiviadis
Nikiteas, Nikolaos
Papavassiliou,
Athanasios G.
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
TGF-beta signalling pathway; Colorectal cancer (CRC); Targeted therapy
DOI:
10.1016/j.canlet.2011.09.041
