Detectable clonal mosaicism and its relationship to aging and cancer

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3155700 64 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Detectable clonal mosaicism and its relationship to aging and cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls
from 13 genome-wide association studies, we observed large chromosomal
abnormalities in a subset of clones in DNA obtained from blood or buccal
samples. We observed mosaic abnormalities, either aneuploidy or
copy-neutral loss of heterozygosity, of > 2 Mb in size in autosomes of
517 individuals (0.89%), with abnormal cell proportions of between 7%
and 95%. In cancer-free individuals, frequency increased with age, from
0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 x
10(-8)). Mosaic abnormalities were more frequent in individuals with
solid tumors (0.97% versus 0.74% in cancer-free individuals; odds
ratio (OR) = 1.25; P = 0.016), with stronger association with cases who
had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005).
Detectable mosaicism was also more common in individuals for whom DNA
was collected at least 1 year before diagnosis with leukemia compared to
cancer-free individuals (OR = 35.4; P = 3.8 x 10(-11)). These findings
underscore the time-dependent nature of somatic events in the etiology
of cancer and potentially other late-onset diseases.
Έτος δημοσίευσης:
2012
Συγγραφείς:
Jacobs, Kevin B.
Yeager, Meredith
Zhou, Weiyin
Wacholder,
Sholom
Wang, Zhaoming
Rodriguez-Santiago, Benjamin and
Hutchinson, Amy
Deng, Xiang
Liu, Chenwei
Horner,
Marie-Josephe
Cullen, Michael
Epstein, Caroline G.
Burdett,
Laurie
Dean, Michael C.
Chatterjee, Nilanjan
Sampson, Joshua
and Chung, Charles C.
Kovaks, Joseph
Gapstur, Susan M. and
Stevens, Victoria L.
Teras, Lauren T.
Gaudet, Mia M. and
Albanes, Demetrius
Weinstein, Stephanie J.
Virtamo, Jarmo and
Taylor, Philip R.
Freedman, Neal D.
Abnet, Christian C. and
Goldstein, Alisa M.
Hu, Nan
Yu, Kai
Yuan, Jian-Min
Liao,
Linda
Ding, Ti
Qiao, You-Lin
Gao, Yu-Tang
Koh, Woon-Puay
and Xiang, Yong-Bing
Tang, Ze-Zhong
Fan, Jin-Hu
Aldrich,
Melinda C.
Amos, Christopher
Blot, William J.
Bock, Cathryn
H.
Gillanders, Elizabeth M.
Harris, Curtis C.
Haiman,
Christopher A.
Henderson, Brian E.
Kolonel, Laurence N.
Le
Marchand, Loic
McNeill, Lorna H.
Rybicki, Benjamin A. and
Schwartz, Ann G.
Signorello, Lisa B.
Spitz, Margaret R. and
Wiencke, John K.
Wrensch, Margaret
Wu, Xifeng
Zanetti,
Krista A.
Ziegler, Regina G.
Figueroa, Jonine D. and
Garcia-Closas, Montserrat
Malats, Nuria
Marenne, Gaelle and
Prokunina-Olsson, Ludmila
Baris, Dalsu
Schwenn, Molly and
Johnson, Alison
Landi, Maria Teresa
Goldin, Lynn
Consonni,
Dario
Bertazzi, Pier Alberto
Rotunno, Melissa
Rajaraman,
Preetha
Andersson, Ulrika
Freeman, Laura E. Beane
Berg,
Christine D.
Buring, Julie E.
Butler, Mary A.
Carreon, Tania
and Feychting, Maria
Ahlbom, Anders
Gaziano, J. Michael and
Giles, Graham G.
Hallmans, Goran
Hankinson, Susan E.
Hartge,
Patricia
Henriksson, Roger
Inskip, Peter D.
Johansen,
Christoffer
Landgren, Annelie
McKean-Cowdin, Roberta and
Michaud, Dominique S.
Melin, Beatrice S.
Peters, Ulrike and
Ruder, Avima M.
Sesso, Howard D.
Severi, Gianluca
Shu,
Xiao-Ou
Visvanathan, Kala
White, Emily
Wolk, Alicja and
Zeleniuch-Jacquotte, Anne
Zheng, Wei
Silverman, Debra T. and
Kogevinas, Manolis
Gonzalez, Juan R.
Villa, Olaya
Li,
Donghui
Duell, Eric J.
Risch, Harvey A.
Olson, Sara H. and
Kooperberg, Charles
Wolpin, Brian M.
Jiao, Li
Hassan, Manal
and Wheeler, William
Arslan, Alan A.
Bueno-de-Mesquita, H. Bas
and Fuchs, Charles S.
Gallinger, Steven
Gross, Myron D. and
Holly, Elizabeth A.
Klein, Alison P.
LaCroix, Andrea and
Mandelson, Margaret T.
Petersen, Gloria
Boutron-Ruault,
Marie-Christine
Bracci, Paige M.
Canzian, Federico
Chang,
Kenneth
Cotterchio, Michelle
Giovannucci, Edward L.
Goggins,
Michael
Bolton, Judith A. Hoffman
Jenab, Mazda
Khaw, Kay-Tee
and Krogh, Vittorio
Kurtz, Robert C.
McWilliams, Robert R. and
Mendelsohn, Julie B.
Rabe, Kari G.
Riboli, Elio
Tjonneland,
Anne
Tobias, Geoffrey S.
Trichopoulos, Dimitrios
Elena,
Joanne W.
Yu, Herbert
Amundadottir, Laufey and
Stolzenberg-Solomon, Rachael Z.
Kraft, Peter
Schumacher,
Fredrick
Stram, Daniel
Savage, Sharon A.
Mirabello, Lisa and
Andrulis, Irene L.
Wunder, Jay S.
Patino Garcia, Ana and
Sierrasesumaga, Luis
Barkauskas, Donald A.
Gorlick, Richard G.
and Purdue, Mark
Chow, Wong-Ho
Moore, Lee E.
Schwartz,
Kendra L.
Davis, Faith G.
Hsing, Ann W.
Berndt, Sonja I. and
Black, Amanda
Wentzensen, Nicolas
Brinton, Louise A. and
Lissowska, Jolanta
Peplonska, Beata
McGlynn, Katherine A. and
Cook, Michael B.
Graubard, Barry I.
Kratz, Christian P. and
Greene, Mark H.
Erickson, Ralph L.
Hunter, David J.
Thomas,
Gilles
Hoover, Robert N.
Real, Francisco X.
Fraumeni, Jr.,
Joseph F.
Caporaso, Neil E.
Tucker, Margaret
Rothman,
Nathaniel
Perez-Jurado, Luis A.
Chanock, Stephen J.
Περιοδικό:
Nature Genetics
Εκδότης:
Nature Publishing Group
Τόμος:
44
Αριθμός / τεύχος:
6
Σελίδες:
651-U68
Επίσημο URL (Εκδότης):
DOI:
10.1038/ng.2270
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