Περίληψη:
Background: Limited scientific evidence has characterized the
association between dietary fiber intake and risk of breast cancer (BC)
by menopausal status and hormone receptor expression in tumors. ‘
Objective: We investigated the relation between total dietary fiber and
its main food sources (vegetables, fruit, cereals, and legumes) and BC
risk by using data from the European Prospective Investigation into
Cancer and Nutrition (EPIC).
Design: A total of 11,576 invasive BC cases in 334,849 EPIC women mostly
aged 35-70 y at baseline were identified over a median follow-up of 11.5
y. Dietary fiber was estimated from country-specific dietary
questionnaires. Multivariable Cox proportional hazards regression models
were used to quantify the association between dietary variables and BC
risk with energy adjustment by using the residual method. Subgroup
analyses were performed by menopausal status and estrogen receptor (ER)
and progesterone receptor (PR) expression in tumors.
Results: BC risk was inversely associated with intakes of total dietary
fiber [hazard ratio comparing fifth quintile to first quintile
(HRQ5-Q1): 0.95; 95% CI: 0.89, 1.01; P-trend = 0.03] and fiber from
vegetables (0.90; 0.84, 0.96; P-trend < 0.01) but not with fiber from
fruit, cereals, or legumes. Overall, associations were homogeneous by
menopausal status and ER and PR expression in tumors. For vegetable
fiber, stronger associations were observed for estrogen
receptor-negative and progesterone receptor-negative (HRQ5-Q1: 0.74;
95% CI: 0.59, 0.93; P-trend = 0.01) than for estrogen receptor-positive
and progesterone receptor-positive tumors (0.92: 0.81, 1.03; P-trend =
0.05), with P-heterogeneity = 0.09.
Conclusion: Diets rich in dietary fiber and, particularly, fiber from
vegetables may be associated with a small reduction in risk of BC,
independently of menopausal status. Am J Clin Nutr 2013;97:344-53.
Συγγραφείς:
Ferrari, Pietro
Rinaldi, Sabina
Jenab, Mazda
Lukanova,
Annekatrin
Olsen, Anja
Tjonneland, Anne
Overvad, Kim and
Clavel-Chapelon, Francoise
Fagherazzi, Guy
Touillaud, Marina and
Kaaks, Rudolf
von Ruesten, Anne
Boeing, Heiner
Trichopoulou,
Antonia
Lagiou, Pagona
Benetou, Vassiliki
Grioni, Sara and
Panico, Salvatore
Masala, Giovanna
Tumino, Rosario
Polidoro,
Silvia
Bakker, Marije F.
van Gils, Carla H.
Ros, Martine M.
and Bueno-de-Mesquita, H. Bas
Krum-Hansen, Sanda
Engeset, Dagrun
and Skeie, Guri
Pilar, Amiano
Sanchez, Maria-Jose
Buckland,
Genevieve
Ardanaz, Eva
Chirlaque, Dolores
Rodriguez, Laudina
and Travis, Ruth
Key, Tim
Khaw, Kay-Tee
Wareham, Nicholas J.
and Sund, Malin
Lenner, Per
Slimani, Nadia
Norat, Teresa and
Aune, Dagfinn
Riboli, Elio
Romieu, Isabelle
