Τίτλος:
Serum Folate and B12 Levels in Association With Cognitive Impairment
Among Seniors: Results From the VELESTINO Study in Greece and
Meta-Analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To summarize existing evidence on the effect of serum folate
and vitamin B12 levels on cognitive impairment among elders via a
meta-analysis, also including unpublished data from a cross-sectional
study of seniors ( > 65 years) residing in Velestino, Greece. Method:
Serum measurements and Mini-Mental State Examination (MMSE) assessments
were available for 593 Velestinians. In addition, 12 studies availing
data on folate blood levels (N = 9,747) and 9 on B12 (N = 8,122) were
identified following a search algorithm; pooled effect estimates were
derived. Results: Cognitive impairment (MMSE < 24) among Velestenians
was associated with lower education level in both genders; decreased
social activity, depressive symptoms and low folate levels in males;
older age in females. Meta-analyses showed an adverse effect of
low-folate levels on cognition (OR: 1.66, 95% CI: 1.40-1.96); B12 was
nonsignificantly associated (OR: 1.11, 95% CI: 0.88-1.40). Discussion:
Low folate levels are associated with cognitive impairment of seniors;
underlying pathophysiological mechanisms should be further explored.
Συγγραφείς:
Michelakos, Theodoros
Kousoulis, Antonis A.
Katsiardanis,
Konstantinos
Dessypris, Nick
Anastasiou, Anastasia and
Katsiardani, Kalliopi-Penelopi
Kanavidis, Prodromos
Stefanadis,
Christodoulos
Papadopoulos, Fotios C.
Petridou, Eleni Th
Περιοδικό:
Journal of Aging and Health
Εκδότης:
SAGE Publications Inc.
Λέξεις-κλειδιά:
folate; B12; cognitive impairment; meta-analysis; aged
DOI:
10.1177/0898264313482488
