Τίτλος:
Acute effects of ambient ozone on mortality in Europe and North America:
results from the APHENA study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The “Air Pollution and Health: A Combined European and North American
Approach” (APHENA) project is a collaborative analysis of multi-city
time-series data on the association between air pollution and adverse
health outcomes. The main objective of APHENA was to examine the
coherence of findings of time-series studies relating short-term
fluctuations in air pollution levels to mortality and morbidity in 125
cities in Europe, the US, and Canada. Multi-city time-series analysis
was conducted using a two-stage approach. We used Poisson regression
models controlling for overdispersion with either penalized or natural
splines to adjust for seasonality. Hierarchical models were used to
obtain an overall estimate of excess mortality associated with ozone and
to assess potential effect modification. Potential effect modifiers were
city-level characteristics related to exposure to other ambient air
pollutants, weather, socioeconomic status, and the vulnerability of the
population. Regionally pooled risk estimates from Europe and the US were
similar; those from Canada were substantially higher. The pooled
estimated excess relative risk associated with a 10 mu g/m(3) increase
in 1 h daily maximum O-3 was 0.26 % (95 % CI, 0.15 %, 0.37 %).
Across regions, there was little consistent indication of effect
modification by age or other effect modifiers considered in the
analysis. The findings from APHENA on the effects of O-3 on mortality in
the general population were comparable with previously reported results
and relatively robust to the method of data analysis. Overall, there was
no indication of strong effect modification by age or ecologic variables
considered in the analysis.
Συγγραφείς:
Peng, Roger D.
Samoli, Evangelia
Luu Pham
Dominici,
Francesca
Touloumi, Giota
Ramsay, Tim
Burnett, Richard T.
and Krewski, Daniel
Le Tertre, Alain
Cohen, Aaron
Atkinson,
Richard W.
Anderson, H. Ross
Katsouyanni, Klea
Samet,
Jonathan M.
Περιοδικό:
Air Quality, Atmosphere and Health
Εκδότης:
SPRINGER INTERNATIONAL PUBLISHING AG
Λέξεις-κλειδιά:
Ozone; Mortality; Time-series; Multi-city; Cardiovascular; Respiratory
DOI:
10.1007/s11869-012-0180-9
