Τίτλος:
Heart dysfunction induced by choline-deficiency in adult rats: The
protective role of L-carnitine
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Choline is a B vitamin co-factor and its deficiency seems to impair
heart function. Carnitine, a chemical analog of choline, has been used
as adjunct in the management of cardiac diseases. The study investigates
the effects of choline deficiency on myocardial performance in adult
rats and the possible modifications after carnitine administration.
Wistar Albino rats (n=24), about 3 months old, were randomized into four
groups fed with: (a) standard diet (control-CA), (b) choline deficient
diet (CDD), (c) standard diet and carnitine in drinking water 0.15% w/v
(CARN) and (d) choline deficient diet and carnitine (CDD+CARN). After
four weeks of treatment, we assessed cardiac function under isometric
conditions using the Langendorff preparations [Left Ventricular
Developed Pressure (LVDP-mmHg), positive and negative first derivative
of LVDP were evaluated], measured serum homocysteine and brain
natriuretic peptide (BNP) levels and performed histopathology analyses.
In the CDD group a compromised myocardium contractility compared to
control (P=0.01), as assessed by LVDP, was noted along with a
significantly impaired diastolic left ventricular function, as assessed
by (-) dp/dt (P=0.02) that were prevented by carnitine. Systolic force,
assessed by (+) dp/dt, showed no statistical difference between groups.
A significant increase in serum BNP concentration was found in the CDD
group (P<0.004) which was attenuated by carnitine (P<0.05), whereas
homocysteine presented contradictory results (higher in the CDD+CARN
group). Heart histopathology revealed a lymphocytic infiltration of
myocardium and valves in the CDD group that was reduced by carnitine. In
conclusion, choline deficiency in adult rats impairs heart performance;
carnitine acts against these changes. (C) 2013 Elsevier B.V. All rights
reserved.
Συγγραφείς:
Strilakou, Athina A.
Lazaris, Andreas C.
Perelas, Apostolos I.
and Mourouzis, Iordanis S.
Douzis, Ioannis Ch.
Karkalousos,
Petros L.
Stylianaki, Aikaterini Th.
Pantos, Costas I. and
Liapi, Charis A.
Περιοδικό:
European Journal of Pharmacology
Λέξεις-κλειδιά:
Choline deficiency; Carnitine; Rat; Heart performance; Homocysteine;
Brain Natriuretic Peptide (BNP)
DOI:
10.1016/j.ejphar.2013.03.025
