Περίληψη:
Objectives Established risk factors for leukaemia do not explain the
majority of leukaemia cases. Previous studies have suggested the
importance of occupation and related exposures in leukaemogenesis. We
evaluated possible associations between job title and selected hazardous
agents and leukaemia in the European Prospective Investigation into
Cancer and Nutrition.
Methods The mean follow-up time for 241 465 subjects was 11.20 years (SD
2.42 years). During the follow-up period, 477 incident cases of myeloid
and lymphoid leukaemia occurred. Data on 52 occupations considered a
priori to be at high risk of developing cancer were collected through
standardised questionnaires. Occupational exposures were estimated by
linking the reported occupations to a job exposure matrix. Cox
proportional hazard models were used to explore the association between
occupation and related exposures and risk of leukaemia.
Results The risk of lymphoid leukaemia significantly increased for
working in chemical laboratories (HR 8.35, 95% CI 1.58 to 44.24), while
the risk of myeloid leukaemia increased for working in the shoe or other
leather goods industry (HR 2.54, 95% CI 1.28 to 5.06).
Exposure-specific analyses showed a non-significant increased risk of
myeloid leukaemias for exposure to benzene (HR 1.15, 95% CI 0.75 to
1.40; HR=1.60, 95% CI 0.95 to 2.69 for the low and high exposure
categories, respectively). This association was present both for acute
and chronic myeloid leukaemia at high exposure levels. However, numbers
were too small to reach statistical significance.
Conclusions Our findings suggest a possible role of occupational
exposures in the development of both lymphoid and myeloid leukaemia.
Exposure to benzene seemed to be associated with both acute and chronic
myeloid leukaemia.
Συγγραφείς:
Hosnijeh, Fatemeh Saberi
Christopher, Yvette
Peeters, Petra and
Romieu, Isabelle
Xun, Wei
Riboli, Elio
Raaschou-Nielsen, Ole
and Tjonneland, Anne
Becker, Nikolaus
Nieters, Alexandra and
Trichopoulou, Antonia
Bamia, Christina
Orfanos, Philip and
Oddone, Enrico
Lujan-Barroso, Leila
Dorronsoro, Miren and
Navarro, Carmen
Barricarte, Aurelio
Molina-Montes, Esther and
Wareham, Nick
Vineis, Paolo
Vermeulen, Roel
