Περίληψη:
Increasing evidence suggests that oral microbiota play a pivotal role in
chronic diseases, in addition to the well-established role in
periodontal disease. Moreover, recent studies suggest that oral bacteria
may also be involved in carcinogenesis; periodontal disease has been
linked to several cancers. In this study, we examined whether lifestyle
factors have an impact on antibody levels to oral bacteria.
Data on demographic characteristics, lifestyle factors, and medical
conditions were obtained at the time of blood sample collection. For the
current analysis, we measured antibody levels to 25 oral bacteria in 395
cancer-free individuals using an immunoblot array. Combined total
immunoglobin G (IgG) levels were obtained by summing concentrations for
all oral bacteria measured.
IgG antibody levels were substantially lower among current and former
smokers (1,697 and 1,677 ng/mL, respectively) than never smokers (1,960
ng/mL; p trend = 0.01), but did not vary by other factors, including
body mass index, diabetes, physical activity, or by dietary factors,
after adjusting for age, sex, education, country, and smoking status.
The highest levels of total IgG were found among individuals with low
education (2,419 ng/mL).
Our findings on smoking are consistent with previous studies and support
the notion that smokers have a compromised humoral immune response.
Moreover, other major factors known to be associated with inflammatory
markers, including obesity, were not associated with antibody levels to
a large number of oral bacteria.
Συγγραφείς:
Michaud, Dominique S.
Izard, Jacques
Rubin, Zachary and
Johansson, Ingegerd
Weiderpass, Elisabete
Tjonneland, Anne and
Olsen, Anja
Overvad, Kim
Boutron-Ruault, Marie Christine and
Clavel-Chapelon, Francoise
Dossus, Laure
Kaaks, Rudolf and
Katzke, Verena A.
Boeing, Heiner
Foerster, Jana and
Trichopoulou, Antonia
Naska, Androniki
Ziara, Giana
Vineis,
Paolo
Grioni, Sara
Palli, Domenico
Tumino, Rosario and
Mattiello, Amalia
Peeters, Petra H. M.
Siersema, Peter D. and
Barricarte, Aurelio
Huerta, Jose-Maria
Molina-Montes, Esther and
Dorronsoro, Miren
Ramon Quiros, J.
Duell, Eric J.
Ohlsson,
Bodil
Jeppsson, Bengt
Johansson, Anders
Lif, Pernilla and
Khaw, Kay-Tee
Wareham, Nick
Travis, Ruth C.
Key, Tim J. and
Freisling, Heinz
Duarte-Salles, Talita
Stepien, Magdalena and
Riboli, Elio
Bueno-de-Mesquita, H. Bas
