Τίτλος:
Angiopoietin-2 Primes Infection-Induced Preterm Delivery
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Current knowledge on the participation of angiopoietin-2 (Ang-2) in the
inflammatory process and on the importance of bacterial endotoxins (LPS)
in the induction of preterm delivery (PTD) led us to investigate the
role of Ang-2/LPS interplay in the pathogenesis of PTD. At a first
stage, Ang-2 was measured at the end of the first trimester of pregnancy
in the serum of 50 women who delivered prematurely; of 88 women
well-matched for age and parity who delivered full-term; and of 20
non-pregnant healthy women. Ang-2 was greater in pregnant than in
non-pregnant women. The time until delivery was shorter among those with
Ang-2 greater than 4 ng/ml (odds ratio for delivery until week 34; p:
0.040). To further investigate the role of Ang-2 for PTD, an
experimental model of PTD induced by the intraperitoneal injection of
LPS in mice was used. Ang-2 was administered intraperitoneally before
LPS on day 14 of pregnancy. When Ang-2 was administered before the LPS
diluent, all mice delivered full-term. However, administration of Ang-2
prior LPS accelerated further the time until delivery. Sacrifice
experiments showed that the effect of Ang-2 was accompanied by decrease
of the penetration of Evans Blue in the embryos and by increase of its
penetration in maternal tissues. In parallel, the concentration of
tumour necrosis factor-alpha in the maternal circulation, in fetal
tissues and in the placentas was significantly decreased. Results
indicate that Ang-2 accelerated the phenomena of PTD induced by LPS.
This is related with deprivation of fetal perfusion.
Συγγραφείς:
Polyzou, Electra N.
Evangelinakis, Nikolaos E.
Pistiki,
Aikaterini
Kotsaki, Antigone
Siristatidis, Charalampos S. and
Chrelias, Charalambos G.
Salamalekis, Emmanuel
Kassanos,
Demetrios P.
Giamarellos-Bourboulis, Evangelos J.
Εκδότης:
Public Library of Science
DOI:
10.1371/journal.pone.0086523
