Περίληψη:
Background: Prognostic value of NT-proBNP is well established in
patients with congenital heart disease. Growing evidence suggests that
plasma NGAL is elevated in heart failure but data is limited in
congenital heart disease. This study investigates the combined
prognostic value of plasma NGAL with plasma NT-proBNP in adult patients
with congenital heart disease.
Methods: Plasma levels of NT-proBNP and NGAL were measured in 76
consecutive adult patients (33 men, mean age 31.7 +/- 14 yrs) with
congenital heart disease and normal values of serum creatinine. Patients
were divided in three groups: A: simple cardiac lesions, B: complex
cardiac lesions and C: cyanotic lesions. Patients were also monitored
for long-term major cardiovascular events: death, hospitalization, NYHA
class worsening, new onset of arrhythmias, surgical or percutaneous
intervention.
Results: NGAL value was significantly different between groups: In group
A median NGAL value was 64.5 +/- 36.7 ng/ml, in group B median NGAL
value was 88.77 +/- 36.17 ng/ml and in group C median NGAL value was 121
+/- 40 ng/ml (group A vs. group B: p = 0.048, group B vs. group C: p =
0.037, group A vs. group C: p = 0.003). Plasma NT-proBNP predicted all
events (HR = 1.001, CI = 1.001-1.002, p = 0.0006) as well as
cardiovascular death alone (HR = 1.001, CI = 1.001-1.002, p = 0.0004);
plasma NGAL was the only predictor of cardiovascular death (HR = 1.017,
CI = 1.001-1.033, p = 0.037).
Conclusion: Plasma NGAL levels were lower in patients with simple
congenital disease compared to patients with complex congenital heart
disease and cyanotic congenital heart disease. Plasma NGAL levels
correlated with NT-proBNP and could predict cardiovascular death in this
small cohort of patients. (C) 2014 Elsevier Ireland Ltd. All rights
reserved.
Συγγραφείς:
Frogoudaki, Alexandra
Andreou, Constantinos
Parissis, John and
Maniotis, Christos
Nikolaou, Maria
Rizos, Ioannis and
Filippatos, Gerasimos
Lekakis, John
