Τίτλος:
Differentiation of BIRADS-4 small breast lesions via Multimodal
Ultrasound Tomography
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose To demonstrate the use of a new 3D diagnostic imaging
technology, termed Multimodal Ultrasonic Tomography (MUT), for the
detection of solid breast lesions <15 mm in maximum dimension.
Methods and materials 3D MUT imaging was performed on 71 volunteers
presenting BIRADS-4 nodules, asymmetrical densities, and architectural
distortions in X-ray mammograms, who subsequently underwent biopsy. MUT
involved D tomographic imaging of the pendulant breast in a water bath
using transmission ultrasound and constructed multimodal images
corresponding to refractivity and frequency-dependent attenuation
(calibrated relative to water). The multimodal images were fused into
composite images and a composite index (CI) was calculated and used for
diagnostic purposes. The composite images were evaluated against results
of histopathology on biopsy specimens.
Results Histopathology revealed 22 malignant and 49 benign lesions. The
pixels of 22 malignant lesions exhibited high values in both
refractivity and attenuation, resulting in CI values>1. In contrast,
99.9% of benign lesions and normal tissue pixels exhibited lower values
of at least one of the attributes measured, corresponding to CI
values<1.
Conclusions MUT imaging appears to differentiate small malignant solid
breast lesions as exhibiting CI values >1, while benign lesions or
normal breast tissues exhibit CI values <1.
Συγγραφείς:
Zografos, G.
Liakou, P.
Koulocheri, D.
Liovarou, I. and
Sofras, M.
Hadjiagapis, S.
Orme, M.
Marmarelis, V.
Περιοδικό:
European Radiology Experimental
Λέξεις-κλειδιά:
Breast cancer detection; Ultrasound tomography; Multimodal ultrasound;
Lesion differentiation; 3D breast imaging
DOI:
10.1007/s00330-014-3415-3
