Περίληψη:
Background: Neopterin may be relevant for colorectal cancer (CRC)
development, as a biomarker of cellular immune activity exerting
pleiotropic effects on cellular ageing, oxidative stress, and
inflammation. So far, the association between prediagnostic neopterin
and colon and rectal cancer risk has not been evaluated in human
populations.
Methods: A nested case-control study was conducted within the European
Prospective Investigation into Cancer and Nutrition cohort using data on
plasma concentrations of total neopterin (T-N, sum of neopterin and
7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and
269 rectal) matched within risk sets to 830 control participants. A
subsequent replication study used data from the Hordaland Health Study,
where 173 CRC case patients have been diagnosed among 6594 healthy
participants over 12 years of follow-up.
Results: After multivariable adjustment for a priori chosen CRC risk
factors, a “U-shaped” association of T-N with CRC was revealed.
Compared with the second quintile of the T-N distribution, the relative
risks for the first, third, fourth, and fifth quintiles were 2.37 (95%
CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08
to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication
of these associations within the Hordaland Health Study yielded similar
results. No differences have been observed when the associations were
explored by colon and rectal cancer site (two-sided P-difference = .87)
and after excluding case patients diagnosed within the first four
follow-up years.
Conclusions: These novel findings provide evidence of the role of both
suppressed and activated cell-mediated immunity as reflected by
prediagnostic T-N concentrations in the development of CRC.
Συγγραφείς:
Aleksandrova, Krasimira
Chuang, Shu-Chun
Boeing, Heiner
Zuo,
Hui
Tell, Grethe S.
Pischon, Tobias
Jenab, Mazda and
Bueno-de-Mesquita, Bas
Vollset, Stein Emil
Midttun, Oivind and
Ueland, Per Magne
Fedirko, Veronika
Johansson, Mattias and
Weiderpass, Elisabete
Severi, Gianluca
Racine, Antoine and
Boutron-Ruault, Marie-Christine
Kaaks, Rudolf
Kuehn, Tilman and
Tjonneland, Anne
Overvad, Kim
Ramon Quiros, J.
Jakszyn,
Paula
Sanchez, Maria-Jose
Dorronsoro, Miren
Chirlaque,
Maria-Dolores
Ardanaz, Eva
Khaw, Kay-Tee
Wareham, Nicholas
J.
Travis, Ruth C.
Trichopoulou, Antonia
Lagiou, Pagona and
Trichopoulos, Dimitrios
Palli, Domenico
Sieri, Sabina and
Tumino, Rosario
Panico, Salvatore
May, Anne M.
Palmqvist,
Richard
Ljuslinder, Ingrid
Kong, So Yeon J.
Freisling, Heinz
and Gunter, Marc J.
Lu, Yunxia
Cross, Amanda J.
Riboli, Elio
and Vineis, Paolo
