Περίληψη:
Background: Cancer survivors are advised to follow lifestyle
recommendations on diet, physical activity, and body fatness proposed by
the World Cancer Research Fund/American Institute of Cancer Research
(WCRF/AICR) for cancer prevention. Previous studies have demonstrated
that higher concordance with these recommendations measured using an
index score (the WCRF/AICR score) was associated with lower cancer
incidence and mortality. The aim of this study was to evaluate the
association between pre-diagnostic concordance with WCRF/AICR
recommendations and mortality in colorectal cancer (CRC) patients.
Methods: The association between the WCRF/AICR score (score range 0-6 in
men and 0-7 in women; higher scores indicate greater concordance)
assessed on average 6.4 years before diagnosis and CRC-specific (n =
872) and overall mortality (n = 1,113) was prospectively examined among
3,292 participants diagnosed with CRC in the European Prospective
Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up
time after diagnosis 4.2 years). Multivariable Cox proportional hazard
models were used to estimate hazard ratios (HRs) and 95% confidence
intervals (CIs) for mortality.
Results: The HRs (95% CIs) for CRC-specific mortality among
participants in the second (score range in men/women:
2.25-2.75/3.25-3.75), third (3-3.75/4-4.75), and fourth (4-6/5-7)
categories of the score were 0.87 (0.72-1.06), 0.74 (0.61-0.90), and
0.70 (0.56-0.89), respectively (P for trend <0.0001), compared to
participants with the lowest concordance with the recommendations
(category 1 of the score: 0-2/0-3). Similar HRs for overall mortality
were observed (P for trend 0.004). Meeting the recommendations on body
fatness and plant food consumption were associated with improved
survival among CRC cases in mutually adjusted models.
Conclusions: Greater concordance with the WCRF/AICR recommendations on
diet, physical activity, and body fatness prior to CRC diagnosis is
associated with improved survival among CRC patients.
Συγγραφείς:
Romaguera, Dora
Ward, Heather
Wark, Petra A.
Vergnaud,
Anne-Claire
Peeters, Petra H.
van Gils, Carla H.
Ferrari,
Pietro
Fedirko, Veronika
Jenab, Mazda
Boutron-Ruault,
Marie-Christine
Dossus, Laure
Dartois, Laureen
Hansen,
Camilla Plambeck
Dahm, Christina Catherine
Buckland, Genevieve
and Sanchez, Maria Jose
Dorronsoro, Miren
Navarro, Carmen and
Barricarte, Aurelio
Key, Timothy J.
Trichopoulou, Antonia and
Tsironis, Christos
Lagiou, Pagona
Masala, Giovanna
Pala,
Valeria
Tumino, Rosario
Vineis, Paolo
Panico, Salvatore and
Bueno-de-Mesquita, H. Bas
Siersema, Peter D.
Ohlsson, Bodil and
Jirstrom, Karin
Wennberg, Maria
Nilsson, Lena M.
Weiderpass,
Elisabete
Kuehn, Tilman
Katzke, Verena
Khaw, Kay-Tee and
Wareham, Nick J.
Tjonneland, Anne
Boeing, Heiner
Quiros,
Jose R.
Gunter, Marc J.
Riboli, Elio
Norat, Teresa
