Τίτλος:
Birthweight and Childhood Cancer: Preliminary Findings from the
International Childhood Cancer Cohort Consortium (I4C)
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
BackgroundEvidence relating childhood cancer to high birthweight is
derived primarily from registry and case-control studies. We aimed to
investigate this association, exploring the potential modifying roles of
age at diagnosis and maternal anthropometrics, using prospectively
collected data from the International Childhood Cancer Cohort
Consortium.
MethodsWe pooled data on infant and parental characteristics and cancer
incidence from six geographically and temporally diverse member cohorts
[the Avon Longitudinal Study of Parents and Children (UK), the
Collaborative Perinatal Project (USA), the Danish National Birth Cohort
(Denmark), the Jerusalem Perinatal Study (Israel), the Norwegian Mother
and Child Cohort Study (Norway), and the Tasmanian Infant Health Survey
(Australia)]. Birthweight metrics included a continuous measure,
deciles, and categories (4.0 vs. <4.0 kilogram). Childhood cancer (377
cases diagnosed prior to age 15 years) risk was analysed by type (all
sites, leukaemia, acute lymphoblastic leukaemia, and non-leukaemia) and
age at diagnosis. We estimated hazard ratios (HR) and 95% confidence
intervals (CI) from Cox proportional hazards models stratified by
cohort.
ResultsA linear relationship was noted for each kilogram increment in
birthweight adjusted for gender and gestational age for all cancers
[HR=1.26; 95% CI 1.02, 1.54]. Similar trends were observed for
leukaemia. There were no significant interactions with maternal
pre-pregnancy overweight or pregnancy weight gain. Birthweight 4.0kg was
associated with non-leukaemia cancer among children diagnosed at age 3
years [HR=1.62; 95% CI 1.06, 2.46], but not at younger ages
[HR=0.7; 95% CI 0.45, 1.24, P for difference=0.02].
ConclusionChildhood cancer incidence rises with increasing birthweight.
In older children, cancers other than leukaemia are particularly related
to high birthweight. Maternal adiposity, currently widespread, was not
demonstrated to substantially modify these associations. Common factors
underlying foetal growth and carcinogenesis need to be further explored.
Συγγραφείς:
Paltiel, Ora
Tikellis, Gabriella
Linet, Martha
Golding, Jean
and Lemeshow, Stanley
Phillips, Gary
Lamb, Karen and
Stoltenberg, Camilla
Haberg, Siri E.
Strom, Marin
Granstrom,
Charlotta
Northstone, Kate
Klebanoff, Mark
Ponsonby,
Anne-Louise
Milne, Elizabeth
Pedersen, Marie
Kogevinas,
Manolis
Ha, Eunhee
Dwyer, Terence
Int Childhood Canc Cohort
Consorti
Περιοδικό:
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
Λέξεις-κλειδιά:
Childhood cancer; leukemia; cohort studies; pooled analysis
