Περίληψη:
Women with a diagnosis of breast cancer are at increased risk of second
primary cancers, and the identification of risk factors for the latter
may have clinical implications. We have followed-up for 11 years 10,045
women with invasive breast cancer from a European cohort, and identified
492 second primary cancers, including 140 contralateral breast cancers.
Expected and observed cases and Standardized Incidence Ratios (SIR) were
estimated using Aalen-Johansen Markovian methods. Information on various
risk factors was obtained from detailed questionnaires and
anthropometric measurements. Cox proportional hazards regression models
were used to estimate the role of risk factors. Women with breast cancer
had a 30% excess risk for second malignancies (95% confidence
interval-CI 18-42) after excluding contralateral breast cancers. Risk
was particularly elevated for colorectal cancer (SIR, 1.71, 95% CI
1.43-2.00), lymphoma (SIR 1.80, 95% CI 1.31-2.40), melanoma (2.12;
1.63-2.70), endometrium (2.18; 1.75-2.70) and kidney cancers (2.40;
1.57-3.52). Risk of second malignancies was positively associated with
age at first cancer, body mass index and smoking status, while it was
inversely associated with education, post-menopausal status and a
history of full-term pregnancy. We describe in a large cohort of women
with breast cancer a 30% excess of second primaries. Among risk factors
for breast cancer, a history of full-term pregnancy was inversely
associated with the risk of second primary cancer.
What’s new? For the first time, researchers have used cohort data to
show that people who survive breast cancer have a higher risk of
developing another cancer later. By collecting data on 10,000 breast
cancer patients over 11 years, these authors calculated a 30% boost in
the patients’ risk of developing a second primary malignancy,
particularly colorectal cancer, lymphoma, melanoma, endometrial cancer,
and kidney cancer. These findings, plus the data they collected on risk
factors such as age, smoking, body mass index, and others, will help
guide clinicians in screening procedures and follow up care for breast
cancer patients.
Συγγραφείς:
Ricceri, Fulvio
Fasanelli, Francesca
Giraudo, Maria Teresa and
Sieri, Sabina
Tumino, Rosario
Mattiello, Amalia
Vagliano,
Liliana
Masala, Giovanna
Ramon Quiros, J.
Travier, Noemie
and Sanchez, Maria-Jose
Larranaga, Nerea
Chirlaque,
Maria-Dolores
Ardanaz, Eva
Tjonneland, Anne
Olsen, Anja and
Overvad, Kim
Chang-Claude, Jenny
Kaaks, Rudolf
Boeing,
Heiner
Clavel-Chapelon, Franc Oise
Kvaskoff, Marina
Dossus,
Laure
Trichopoulou, Antonia
Benetou, Vassiliki
Adarakis,
George
Bueno-de-Mesquita, H. B(As)
Peeters, Petra H.
Sund,
Malin
Andersson, Anne
Borgquist, Signe
Butt, Salma and
Weiderpass, Elisabete
Skeie, Guri
Khaw, Kay-Tee
Travis, Ruth
C.
Rinaldi, Sabina
Romieu, Isabelle
Gunter, Marc
Kadi,
Mai
Riboli, Elio
Vineis, Paolo
Sacerdote, Carlotta
