Περίληψη:
Alcohol intake has been associated to breast cancer in pre and
postmenopausal women; however results are inconclusive regarding tumor
hormonal receptor status, and potential modifying factors like age at
start drinking. Therefore, we investigated the relation between alcohol
intake and the risk of breast cancer using prospective observational
data from the European Prospective Investigation into Cancer and
Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline,
were recruited in ten European countries and followed up an average of
11 years. Alcohol intake at baseline and average lifetime alcohol intake
were calculated from country-specific dietary and lifestyle
questionnaires. The study outcomes were the Hazard ratios (HR) of
developing breast cancer according to hormonal receptor status. During
3,670,439 person-years, 11,576 incident breast cancer cases were
diagnosed. Alcohol intake was significantly related to breast cancer
risk, for each 10 g/day increase in alcohol intake the HR increased by
4.2% (95% CI: 2.7-5.8%). Taking 0 to 5 g/day as reference, alcohol
intake of >5 to 15 g/day was related to a 5.9% increase in breast
cancer risk (95% CI: 1-11%). Significant increasing trends were
observed between alcohol intake and ER+/PR+, ER-/PR-, HER2- and
ER-/PR-HER2- tumors. Breast cancer risk was stronger among women who
started drinking prior to first full-time pregnancy. Overall, our
results confirm the association between alcohol intake and both hormone
receptor positive and hormone receptor negative breast tumors,
suggesting that timing of exposure to alcohol drinking may affect the
risk. Therefore, women should be advised to control their alcohol
consumption.
What’s new? Although it is now established that alcohol consumption
increases breast cancer risk, many questions remain. Using a prospective
study design with 11,576 incident breast cancer cases across 10 European
countries, the authors confirmed the increased risk of alcohol on breast
cancer development. They further show that women who started drinking
before their first full-term pregnancy have a higher risk than women who
started afterwards. These effects were observed in hormone-receptor
positive and -negative tumors pointing to non-hormonal pathways that
need to be further investigated.
Συγγραφείς:
Romieu, Isabelle
Scoccianti, Chiara
Chajes, Veronique
de
Batlle, Jordi
Biessy, Carine
Dossus, Laure
Baglietto, Laura
and Clavel-Chapelon, Francoise
Overvad, Kim
Olsen, Anja and
Tjonneland, Anne
Kaaks, Rudolf
Lukanova, Annekatrin
Boeing,
Heiner
Trichopoulou, Antonia
Lagiou, Pagona
Trichopoulos,
Dimitrios
Palli, Domenico
Sieri, Sabina
Tumino, Rosario and
Vineis, Paolo
Panico, Salvatore
Bueno-de-Mesquita, H. B(as) and
van Gils, Carla H.
Peeters, Petra H.
Lund, Eiliv
Skeie, Guri
and Weiderpass, Elisabete
Quiros Garcia, Jose Ramon
Chirlaque,
Maria-Dolores
Ardanaz, Eva
Sanchez, Maria-Jose
Duell, Eric
J.
Amiano, Pilar
Borgquist, Signe
Wirfalt, Elisabet and
Hallmans, Goran
Johansson, Ingegerd
Nilsson, Lena Maria and
Khaw, Kay-Tee
Wareham, Nick
Key, Timothy J.
Travis, Ruth C.
and Murphy, Neil
Wark, Petra A.
Ferrari, Pietro
Riboli, Elio
